Boceprevir; Ritonavir; Telaprevir/Alprazolam Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process your alprazolam properly.

What might happen:

The blood levels of alprazolam may increase. This may cause toxic effects such as drowsiness, slurred speech, incoordination, or difficulty breathing.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Victrelis (boceprevir) US prescribing information. Schering Corporation January, 2017.
  • 2.Frye R, Bertz R, Granneman GR, Qian J, Lamm J, Dennis S, Valdes J. Effect of ritonavir on the pharmacokinetics and pharmacodynamics of alprazolam. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Toronto, Canada 1997;37:12.
  • 3.Greenblatt DJ, von Moltke LL, Harmatz JS, Durol AL, Daily JP, Graf JA, Mertzanis P, Hoffman JL, Shader RI. Alprazolam-ritonavir interaction: implications for product labeling. Clin Pharmacol Ther 2000 Apr; 67(4):335-41.
  • 4.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2018.
  • 5.Incivek (telaprevir) US prescribing information. Vertex Pharmaceuticals Incorporated October, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.