User Reviews for Xiaflex injection

It did make a difference in reducing the 'curvature' but absolutely did cause shrinkage. I don't believe that this was ever communicated to me. I would have NEVER undergone this procedure if I had any inkling that it would shorten my length.

Painfull, expensive and very little improvement (if any)

Wasted lots of time and lots of money for zero results. As a matter of fact condition got worse.

went through shots for peyronie's disease little or no improvement very expensive waist of money i'm talking about xiaflex to bad we can't sue for malpractice

Very painful injections. Severe swelling in lower legs. Very little improvement

First off, the injection to induced erection failed so the Doctor didn't even see the degree of curvature. Part of my plaque was easily felt and easy to find for injections. Oddly, he would use 2 different amounts, 2 different size syringes/needles for the 2 injection series. He had a nurse in the room for training even though I told him I wasn't comfortable with this. After 2 rounds (4 injections) it was obvious the drug was having no effect. I did have some moderate pain during those injection and severe pain hours later. Mild bruising/swelling. My 3rd round of injections the Doctor told me the Nurse would administer the last one. I told him NO. He did it anyways. Severe pain during injection and I could feel that she was injecting outside the plaque. Hours later I had level 10 pain, swelling and bruising in penis and into my scrotum and lower abdomen. My call to his office was met with "Don't worry. It's normal." although it was nothing like the other injections. End up with massive hematoma, 30 degree right bend turned into 55 degree curve right and upwards and now has two hinges making penetration impossible. My penis changed colors and lost 2 inches length and an inch in girth. The Doctor's response: "Sorry. You'll need to get implants".Read More Read Less

Do not use this. I'm 49. I had curvature of about 35% and should have just left it alone. Instead, I panicked. My urologist said it wouldn't get better, but it could definitely get worse. Starting in June 2021, I had two injections in one week every 6 weeks. The injections are very painful despite a local anesthetic. The side effects are as advertised -- pain, swelling, itching, etc. -- but they dissipate after a few days. I did the stretching exercises religiously. I didn't notice any improvement over the first three sets of injections. It was after the fourth that I experienced a severe hourglass shape to my penis. It got very wide just below the head and then very thin on the bottom third of it. This was never mentioned to me before I started treatment. Nor was the fact that I would lose a significant amount of length and width. I lost approximately two inches and half of my normal width. Additionally, the much thinner shaft and base feels fragile, like it could easily fracture during intercourse. To say my girlfriend was disappointed is an understatement. She and I went from being very satisfied to her disappointed and me in full depression. Size does matter. I had very high hopes for this. Waste of thousands of dollars, excruciating pain and worse embarrassment then when I started treatment. I went from a very confident lover to unable to perform. Read More Read Less

Probably most likely the doc but stay away from this stuff and Joseph Plunkett, MD. PNS

Find a doctor with plenty of experience. I only needed one cycle (two injections) and went from 40 to less than 10 degrees. Of course there was some pain! Duh! But they use numbing meds for the injections. No pain meds except I used some Tylenol PM. I was concerned with the bruising for a couple of days but it went away. The exercises were not a problem and made the difference. Doc said it was a remarkable recovery. The chemically induced erection was more annoying than the injections! I almost cancelled when after reading some of these reviews. If needed, be sure to ask for help in paying the cost. I went to a Univ. of California teaching hospital for treatment which was a good choice. Not every med works the same for every person. Find a doctor you trust.Read More Read Less

I wish I had never done this treatment. My angle of curve was about 60 degrees near the head of my penis. I went through the complete treatment course of 8 injections and followed the instructions of stretching. I experienced serve pain with each injection. On the 2nd round of injections a huge hematoma formed. My MD said that was good and normal. He kept telling me he could feel the plaque breaking up. I never saw nor felt any difference. I now have the 60 degree curve towards the base of my penis and there is a hard substance under the skin from the base up about 2 inches on the top side. If there is a class action against this I will be one of the 1st to sign up!Read More Read Less

Absolutely horrible drug. A huge waste of money and actually made me much worse. The pain is excruciating and If I could go back I would have just went straight to surgery. This is a horrible disease and men who have it are doing all they can to not end their lives. They are preying on the vulnerable and desperate. One review states they hope there is a class action lawsuit. I am in agreement with that. I would discourage anybody even though they are as desperate as I have been. I jumped right in because I felt hopeless. Please absolutely consider the reviews that people have left before doing it. I have done 6 injections. 3 cycles and am scheduled for a 4th cycle but am most likely going to cancel. To all of the men like me, I know how you feel.Read More Read Less

Hopefully there will be a class action against this drug, BEWARE.

This is an absolutely horrible drug and treatment that did nothing to improve my curvature of my penis and actually made things worse. I went through all 8 injections over a 6 month period and followed the instructions to a T but in the end not only did it do nothing to lessen my curve which is about 60% but it made my penis shorter by about an inch. Peyronies shortens your penis anyway by about an inch to an inch and a half so this just devastated me. In the end my penis is more than 2 inches shorter with the same curve. Additionally, I have had pubic area pain that is intermittent which I attribute to the injections. For 6 to 8 months I had a bruised and swollen penis that I had to stretch as part of the treatment which was excruciating and for 6 months after the last injection all I did was cry because it failed. I know that sounds pathetic to some but this is a very lonely disease to deal with and this company who created xiaflex needs to be held accountable for this.Read More Read Less

Although the injections were painful and there was a little bit of pain after the second injection in each series, I am very pleased. After just 2 series, I have gone from 60 to 30 degrees. That is far better than surgery.

Curvature the same, and now base of penis gets no blood! And the â??60 percent experience average of 17 degrees curvature reduction.â? What does that even mean? I knew that going in, but zero degrees? I guess Iâ??m in the 40%. Talk about a Hail Mary.

Worst experience of my life! so painful! This drug should not be given to anyone! Did not help! Made me worse!!

4 sessions and nothing. Not much in the way of monitoring effectiveness during Dr appointments. Felt as if I just showed up for shots and hoped for the best. First appointment Doctor wanted to skip the evaluation process of producing erection to determine amount and direction of curvature. After complaining Doctor induced erection through injection but really didnâ??t spend much time on analysis. Doctor did not wait the recommended time for erection to subside before injecting Xiaflex. Bruising and swelling occurred. On top of it all, the Doctor filled the room with observers without considering the embarrassment factor. Needless to say, I was not pleased. I did not like his using my treatment as his personal teaching moment. I feel that the Doctors performing this treatment should be evaluated and trained better by the Pharmaceutical Company. Follow ups need more effort. For the money I spent would have expected better care and results. Read More Read Less

Terrible experience. My penis now curves upward and hurts like hell. Not to mention severe shrinkage. I have been trying to get an appointment with a specialist out of town and have to wait for 2 months. Stay away from this drug

Decreased pain somewhat , but if I get an erection my bend is still 90 to 95 degrees. Xiaflex did nothing to correct this worthless bend. I have lost 3inches in length since starting with. PD. I am healthy, donâ??t smoke, drink, am a vegetarian, normal weight and BMI. Injections hurt and did nothing .

Two cycles, four shots, no improvement. Why did the FDA approve this drug?