Treat Dupuytren’s Contracture With a Nonsurgical Option

XIAFLEX® Treatment

XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture when a cord can be felt.

Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.

XIAFLEX® is given:

  • In a doctor’s office
  • By a hand specialist with XIAFLEX® training
  • With no general anesthesia required

Treatment with XIAFLEX® begins with finding a XIAFLEX®-trained hand specialist. Use our locator to find one in your area.

Find a hand specialist in your area

What Kind of Results Are Possible?

Individual results may vary. The following are real-world examples of treatment with XIAFLEX®:

Before treatment
After treatmeant

This patient had a cord that could be felt causing a contracture of the MP (metacarpophalangeal) joint of the left ring finger. The cord was injected with XIAFLEX®, and a finger extension procedure was performed 48 hours later.

Before treatment
After treatmeant

This patient had a cord that could be felt causing a contracture of the MP and PIP (proximal interphalangeal) joints of the left pinky finger. The cord was injected with XIAFLEX®, and a finger extension procedure was performed 48 hours later.

Patients had finger extensions performed by a physician; were fitted with a splint; and were instructed to use a splint at bedtime for up to 4 months and perform daily finger exercises.

In studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt at approximately 4-week intervals.

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include swelling of the injection site or the hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; and pain in the armpit.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.

Since 2010, it is estimated that more than 150,000 patients with Dupuytren’s contracture have been treated with XIAFLEX®.* Watch Ed’s story about his treatment experience.

*Through February 2020.

83% (206 out of 249) of patients were satisfied with XIAFLEX® compared with 30% (38 out of 125) of patients with placebo.*

*In 2 clinical studies, patients were asked to rate their satisfaction with treatment on Day 90 as “very satisfied,” “quite satisfied,” “neither satisfied nor dissatisfied,” “quite dissatisfied,” or “very dissatisfied.” For data analysis, “satisfied” includes patients who chose “very satisfied” or “quite satisfied.”

In these 2 clinical studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day.

In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX® injections and finger extension procedures compared with 6% of patients who received placebo.

The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site.

IMPORTANT SAFETY INFORMATION FOR XIAFLEX® (collagenase clostridium histolyticum)

WHAT IS XIAFLEX®?

XIAFLEX is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. It is not known if XIAFLEX is safe and effective in children under the age of 18.

IMPORTANT SAFETY INFORMATION FOR XIAFLEX

Do not receive XIAFLEX if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

  • Tendon rupture or ligament damage. Receiving an injection of XIAFLEX may cause damage to a tendon or ligament in your hand and cause it to break or weaken. This could require surgery to fix the damaged tendon or ligament. Call your healthcare provider right away if you have trouble bending your injected finger (towards the wrist) after the swelling goes down or you have problems using your treated hand after your follow-up visit
  • Nerve injury or other serious injury of the hand. After finger procedures, some people developed tears in the skin (lacerations), and local skin and soft-tissue necrosis (death of skin cells). Some lacerations and necrosis required skin grafting, or other surgery including amputation. Call your healthcare provider right away if you get numbness, tingling, increased pain, or tears in the skin (laceration) in your treated finger or hand after your injection or after your follow-up visit
  • Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX because it contains foreign proteins. Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
  • hives
  • swollen face
  • breathing trouble
  • chest pain
  • low blood pressure
  • dizziness or fainting
  • Increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

The most common side effects with XIAFLEX for the treatment of Dupuytren’s contracture include:

  • swelling of the injection site or the hand
  • bruising or bleeding at the injection site
  • pain or tenderness of the injection site or the hand
  • swelling of the lymph nodes (glands) in the elbow or armpit
  • itching
  • breaks in the skin
  • redness or warmth of the skin
  • pain in the armpit

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Click for full Prescribing Information, including Medication Guide.

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