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How does tissue plasminogen activator (tPA) affect the clotting process?

ANSWER

A clot-dissolving drug called tissue plasminogen activator (tPA) activates the protein that breaks down the fibrin strands. Sometimes doctors prescribe it as a treatment for heart attack or stroke.

SOURCES:

Merck Manual: "How Blood Clots."

World Federation of Hemophilia: "The clotting process."

American Stroke Association: "Anti-Clotting Agents Explained."

Lipe, B. Circulation, Oct. 4, 2011.

Furie, B. New England Journal of Medicine, 2008.

Hoffman, R. Hematology: Basic Principles and Practice, 5th edition, Churchill Livingstone Elsevier, 2009.

Fiumara, K. Circulation, 2009.

Reviewed by Gabriela Pichardo on January 20, 2020

SOURCES:

Merck Manual: "How Blood Clots."

World Federation of Hemophilia: "The clotting process."

American Stroke Association: "Anti-Clotting Agents Explained."

Lipe, B. Circulation, Oct. 4, 2011.

Furie, B. New England Journal of Medicine, 2008.

Hoffman, R. Hematology: Basic Principles and Practice, 5th edition, Churchill Livingstone Elsevier, 2009.

Fiumara, K. Circulation, 2009.

Reviewed by Gabriela Pichardo on January 20, 2020

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Who is most likely to get blood clots?

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