Medications, such as Avastin, Eylea, Lucentis, and Macugen have become the preferred treatments for acute wet macular degeneration, helping to prevent the growth of leaky blood vessels in your eye. Lucentis is given once every month, although some patients may need treatment only once every three months. Macugen is given every six weeks. Eylea is given once every two months after three once-monthly injections. Avastin is not strictly an eye medication, but it is used off-label as one of the most common treatments for wet macular degeneration.