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How do serotonin and norepinephrine reuptake inhibitors help to treat fibromyalgia?

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Serotonin and norepinephrine reuptake inhibitors (SNRIs) can help with pain, sleep problems, and sad moods. The two main SNRI drugs for fibromyalgia are duloxetine (Cymbalta) and milnacipran (Savella).

From: What Medicines Treat Fibromyalgia? WebMD Medical Reference

Reviewed by David Zelman on September 7, 2019

Medically Reviewed on 9/7/2019

SOURCES:

Mayo Clinic: "Fibromyalgia," "Antidepressants: Another Weapon Against Chronic Pain."

FDA: "Living with Fibromyalgia, Drugs Approved to Manage Pain," "Medical Guide for Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)."

Arthritis Foundation: "Fibromyalgia Treatment."

Johns Hopkins Lupus Center: "Fibromyalgia Medications."

American College of Rheumatology: "Fibromyalgia."

Journal of the American Medical Association : "Treatment of Fibromyalgia Syndrome With Antidepressants."

Medscape: "Fibromyalgia Medication."

Journal of Clinical Rheumatology : "Efficacy of Tramadol in Treatment of Pain of Fibromyalgia."

Pain Medicine : "The Effects of Tizanidine HCL (Zanaflex) in Patients With Fibromyalgia."

Reviewed by David Zelman on September 7, 2019

SOURCES:

Mayo Clinic: "Fibromyalgia," "Antidepressants: Another Weapon Against Chronic Pain."

FDA: "Living with Fibromyalgia, Drugs Approved to Manage Pain," "Medical Guide for Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)."

Arthritis Foundation: "Fibromyalgia Treatment."

Johns Hopkins Lupus Center: "Fibromyalgia Medications."

American College of Rheumatology: "Fibromyalgia."

Journal of the American Medical Association : "Treatment of Fibromyalgia Syndrome With Antidepressants."

Medscape: "Fibromyalgia Medication."

Journal of Clinical Rheumatology : "Efficacy of Tramadol in Treatment of Pain of Fibromyalgia."

Pain Medicine : "The Effects of Tizanidine HCL (Zanaflex) in Patients With Fibromyalgia."

Reviewed by David Zelman on September 7, 2019

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How do selective serotonin reuptake inhibitors work to treat fibromyalgia?

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