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What are the different drugs that may interact with Cymbalta and cause serotonin syndrome while treating fibromyalgia?

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Cymbalta (duloxetine) is a type of antidepressant. Rarely, it can lead to a deadly condition called serotonin syndrome. That most often happens when someone takes duloxetine with one or more drugs that also boost your body’s levels of serotonin. Drugs that may interact with Cymbalta and cause serotonin syndrome include:

  • Cough medicines that contain dextromethorphan
  • Monoamine oxidase inhibitors (MAOIs)
  • Nausea and heartburn medications such as metoclopramide (Reglan) and ondansetron (Zofran)
  • Pain medications, including meperidine (Demerol, a painkiller) and tramadol (Ultram)
  • St. John's wort
  • Triptans, used to treat migraine headaches
  • Blood thinners, including warfarin, aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDs

From: Cymbalta for Fibromyalgia Treatment WebMD Medical Reference

SOURCES:

WebMD: "Cymbalta Oral."

Rakel R.E. , 7th ed, 2007; Saunders Elsevier. Textbook of Family Medicine

Cymbalta web site: "Cymbalta and Fibromyalgia."

Savella web site.

Rakel P, Bope E.T. , Saunders Elsevier. Conn's Current Therapy 2007

Reviewed by David Zelman on February 13, 2018

SOURCES:

WebMD: "Cymbalta Oral."

Rakel R.E. , 7th ed, 2007; Saunders Elsevier. Textbook of Family Medicine

Cymbalta web site: "Cymbalta and Fibromyalgia."

Savella web site.

Rakel P, Bope E.T. , Saunders Elsevier. Conn's Current Therapy 2007

Reviewed by David Zelman on February 13, 2018

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What medical conditions that need to be determined before taking Cymbalta to treat fibromyalgia?

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