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What medications can treat fibromyalgia?

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Three medications are FDA-approved to treat fibromyalgia:

  • Cymbalta (duloxetine): Cymbalta is type of antidepressant called a serotonin and norepinephrine reuptake inhibitor (SNRI). Researchers aren't sure how Cymbalta works in fibromyalgia, but they think that increasing levels of serotonin and norepinephrine help control and reduce feelings of pain.
  • Lyrica (pregabalin): Lyrica is a nerve pain and epilepsy drug. In people with fibromyalgia, it may help calm down overly sensitive nerve cells that send pain signals throughout the body. It has been effective in treating fibro pain.
  • Savella (milnacipran): Savella is also an SNRI. While researchers aren't exactly sure how it works, studies have shown that it helps relieve pain and reduce fatigue in people with fibromyalgia.

SOURCES:

Mease, P. , Spring 2008; vol 18: pp 26-35. The Pain Practitioner

National Center for Complementary and Alternative Medicine: “Fibromyalgia and CAM: At a Glance.”

National Institute of Arthritis and Musculoskeletal and Skin Diseases: “Questions and Answers about Fibromyalgia.”

WebMD Medical Reference: “What is Fibromyalgia?;” “Fibromyalgia Medications;” “Fibromyalgia and Exercise;" “Fibromyalgia Treatments;” “Fibromyalgia and Alternative Treatments;” and “Herbs and Supplements for Fibromyalgia.”

National Fibromyalgia Association.  

WebMD Health News: "A Blood Test for Fibromyalgia?"

Reviewed by Carol DerSarkissian on April 27, 2019

SOURCES:

Mease, P. , Spring 2008; vol 18: pp 26-35. The Pain Practitioner

National Center for Complementary and Alternative Medicine: “Fibromyalgia and CAM: At a Glance.”

National Institute of Arthritis and Musculoskeletal and Skin Diseases: “Questions and Answers about Fibromyalgia.”

WebMD Medical Reference: “What is Fibromyalgia?;” “Fibromyalgia Medications;” “Fibromyalgia and Exercise;" “Fibromyalgia Treatments;” “Fibromyalgia and Alternative Treatments;” and “Herbs and Supplements for Fibromyalgia.”

National Fibromyalgia Association.  

WebMD Health News: "A Blood Test for Fibromyalgia?"

Reviewed by Carol DerSarkissian on April 27, 2019

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Can antidepressants treat fibromyalgia?

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