Pick Up Weights to Take Off Pounds

Stronger Muscles Burn More Fat, Rev Up Metabolism in Overweight People, Lab Tests Confirm

From the WebMD Archives

Feb. 5, 2008 -- Weight training may be a health boon for overweight people, new research shows.

Boston University scientists report that "strength training, in addition to ... endurance training, may be of particular benefit to overweight individuals."

The researchers aren't talking about fitting into a smaller-sized pair of jeans or shrinking the numbers on the scale. Instead, they're focused on the metabolism benefits of getting stronger at any size.

Here's their key finding from lab tests on mice: Stronger muscles means more fat burned and a perkier metabolism, even with less-than-stellar diet and exercise habits.

But there's a catch. Muscles don't stay that way without work, so you've got to be in it for the long haul to keep reaping the benefits.

(Is weight training a part of your weight loss plan? Why or why not? Talk about it and get an expert view on WebMD's Exercise & Fitness: Rich Weil, MEd, CDE, message board.)

Mighty Mice

Yasuhiro Izumiya, MD, PhD, and colleagues used genetic engineering to turn a certain muscle gene off and on in mice.

When the gene was on, the mice got a lot more muscular and stronger, mimicking the effects of weight training.

But when the gene was switched off, the mice lost their buff physiques, as if they'd slacked off a strength-training program.

Those mice shed more fat, had livelier metabolisms, and responded better to insulin (a hormone made by their bodies to control blood sugar) when they were muscular.

That pattern held even when the mice ate fatty, sugary chow and didn't get much exercise. However, those mice did wind up fatter than active mice on a healthier diet.

The mice's metabolic benefits stemmed from their type 2 muscle fibers, which are strengthened by weight training, Izumiya's team notes in Cell Metabolism.

But strength training is just one part of fitness. In Izumiya's study, when the mice got very muscular, their grips became stronger, but they didn't fare too well on a treadmill test. So while weight training may help with weight loss, endurance training is still important.

Consult your doctor before starting a new exercise program, especially if you've been on the sidelines for a while.

WebMD Health News Reviewed by Louise Chang, MD on February 05, 2008


Izumiya, I. Cell Metabolism, Feb. 6, 2008; vol 7: pp 159-172.
News release, Boston University.
News release, Cell Press.

© 2008 WebMD, LLC. All rights reserved.

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