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How do H2 blockers treat heartburn and reflux?

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Prescription histamine-2 (or H2) blockers are usually higher doses than over-the-counter versions. They're quite good at relieving heartburn, but may not be as good for treating the inflammation in the esophagus that results from GERD:

Histamine triggers acid production, especially after meals, so H2 blockers are best taken 30 minutes before meals. You can also take them at bedtime.

  • Cimetidine (Tagamet HB200)
  • Famotidine (Pepcid)
  • Nizatidine (Axid)
  • Ranitidine (Zantac)

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How do proton pump inhibitors treat heartburn and reflux?

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