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What are the side effects of prokinetics for heartburn?

ANSWER

Prokinetics can have more serious side effects than proton-pump inhibitors or H2 blockers. These include:

  • Anxiety
  • Depression
  • Diarrhea
  • Drowsiness
  • Fatigue
  • Irritability
  • Nausea
  • Problems with movement

From: Heartburn Relief Tips WebMD Medical Reference

SOURCES:

AHRQ: “Treatment Options for GERD or Acid Reflux Disease: A Review of the Research for Adults.”

American Academy of Family Physicians: “Heartburn.”

American College of Gastroenterology: “Acid Reflux.”

American Gastroenterological Association: “Understanding Heartburn and Reflux Disease.”

American Society for Gastrointestinal Endoscopy: “Understanding Gastroesophageal Reflux Disease.”

American Society of Health-System Pharmacists: “Cimetidine.”

Brahm, N. , April 2011. The Consultant Pharmacist

Cleveland Clinic: “GERD and Asthma.”

FDA: “Possible Increased Risk of Bone Fractures with Certain Antacid Drugs.”

Hye-kyung J. , January 2010. Journal of Neurogastroenterol Motility

International Foundation for Functional Gastrointestinal Disorders: “Exercise & GI Symptoms.”

Katz, P. , 2013. American Journal of Gastroenterology

NHLBI: “What are the symptoms of a heart attack?”

NIDDK: “Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Adults.”

Thompson, W. International Foundation for Functional Gastrointestinal Disorders.

Reviewed by James Beckerman on May 2, 2019

SOURCES:

AHRQ: “Treatment Options for GERD or Acid Reflux Disease: A Review of the Research for Adults.”

American Academy of Family Physicians: “Heartburn.”

American College of Gastroenterology: “Acid Reflux.”

American Gastroenterological Association: “Understanding Heartburn and Reflux Disease.”

American Society for Gastrointestinal Endoscopy: “Understanding Gastroesophageal Reflux Disease.”

American Society of Health-System Pharmacists: “Cimetidine.”

Brahm, N. , April 2011. The Consultant Pharmacist

Cleveland Clinic: “GERD and Asthma.”

FDA: “Possible Increased Risk of Bone Fractures with Certain Antacid Drugs.”

Hye-kyung J. , January 2010. Journal of Neurogastroenterol Motility

International Foundation for Functional Gastrointestinal Disorders: “Exercise & GI Symptoms.”

Katz, P. , 2013. American Journal of Gastroenterology

NHLBI: “What are the symptoms of a heart attack?”

NIDDK: “Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Adults.”

Thompson, W. International Foundation for Functional Gastrointestinal Disorders.

Reviewed by James Beckerman on May 2, 2019

NEXT QUESTION:

Should you call your doctor if your medications don't help with your heartburn?

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