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Does Harvoni have side effects?

ANSWER

The majority of those who take ledipasvir-sofosbuvir (Harvoni) don’t have side effects. But some people get more tired than usual or have headaches.

Other rare side effects include:

Tell your doctor if you have hepatitis B because it can flare up or reactivate if you take Harvoni. They'll likely test you for hep B before you start on the drug. Tell your doctor about any medications you take because they could affect how Harvoni works and if it's safe for you. For example, the heart medication amiodarone (Pacerone) in particular may not work well with it.

  • Diarrhea
  • Insomnia
  • Nausea

SOURCES:

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability of Economic Evaluation Studies: Is There a Generally Accepted Alternative Price Benchmark to the Wac Price?”

Hepatitis C Online: "Ledipasvir-Sofosbuvir (Harvoni)."

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease.”

Reviewed by Melinda Ratini on May 30, 2020

SOURCES:

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability of Economic Evaluation Studies: Is There a Generally Accepted Alternative Price Benchmark to the Wac Price?”

Hepatitis C Online: "Ledipasvir-Sofosbuvir (Harvoni)."

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease.”

Reviewed by Melinda Ratini on May 30, 2020

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