PREVIOUS QUESTION:

 

NEXT QUESTION:

 

How does genotype affect treatment for hep C?

ANSWER

Your specific genotype can tell your doctor important things about how to use those medications, what to watch for, and other drugs you might need. For example, you may have a higher chance for cirrhosis (serious liver scarring) if you have genotype 1. Genotype 3, the second most common subtype worldwide, may not respond as well to DAAs alone. In addition, this type might suggest that:

?Liver disease may progress more quickly.

?Liver cancer is more likely.

?Insulin resistance might happen. When your body resists or doesn't respond to insulin as well as normal, heart disease and diabetes are more likely.

?You might need longer, more challenging treatment (especially if you have cirrhosis or liver disease, or if you've had a previous treatment)

SOURCES:

American Association for the Study of Liver Diseases: “Initial Treatment of Adults with HCV Infection,” “HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.”

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “HCV Genotypes,” “Hepatitis C Virus (HCV) Diagnostics Fact Sheet,” “Genotypes of hepatitis C,” “Harvoni.”

Treatment Action Group: “Hepatitis C Virus (HCV) Diagnostics Fact Sheet,” “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability Of Economic

Evaluation Studies: Is There A Generally Accepted Alternative Price Benchmark To The Wac Price?”

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease,” “Chronic Hepatitis C Virus (HCV) Infection: Treatment Considerations.”

Reviewed by Brunilda Nazario on June 01, 2020

SOURCES:

American Association for the Study of Liver Diseases: “Initial Treatment of Adults with HCV Infection,” “HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C.”

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “HCV Genotypes,” “Hepatitis C Virus (HCV) Diagnostics Fact Sheet,” “Genotypes of hepatitis C,” “Harvoni.”

Treatment Action Group: “Hepatitis C Virus (HCV) Diagnostics Fact Sheet,” “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability Of Economic

Evaluation Studies: Is There A Generally Accepted Alternative Price Benchmark To The Wac Price?”

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease,” “Chronic Hepatitis C Virus (HCV) Infection: Treatment Considerations.”

Reviewed by Brunilda Nazario on June 01, 2020

NEXT QUESTION:

When might my doctor change my hep C treatment?

WAS THIS ANSWER HELPFUL

"ALEXA, ASK WEBMD"

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

    This tool does not provide medical advice. See additional information.