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How does Harvoni work?

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Ledipasvir-sofosbuvir (Harvoni) is a combination of two drugs. Each one blocks a protein that the hep c virus needs in order to grow: Ledipasvir blocks a protein called NS5A. Sofosbuvir blocks an enzyme called NS5B RNA-dependent RNA polymerase.

SOURCES:

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability of Economic Evaluation Studies: Is There a Generally Accepted Alternative Price Benchmark to the Wac Price?”

Hepatitis C Online: "Ledipasvir-Sofosbuvir (Harvoni)."

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease.”

Reviewed by Melinda Ratini on May 30, 2020

SOURCES:

CDC: “Hepatitis C Questions and Answers for the Public.”

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Ledipasvir-Sofosbuvir (Harvoni).”

Merck Manual: “Overview of Chronic Hepatitis.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability of Economic Evaluation Studies: Is There a Generally Accepted Alternative Price Benchmark to the Wac Price?”

Hepatitis C Online: "Ledipasvir-Sofosbuvir (Harvoni)."

U.S. Department of Veterans Affairs: “Viral Hepatitis and Liver Disease.”

Reviewed by Melinda Ratini on May 30, 2020

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