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What are the treatments for chronic hepatitis C?

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For chronic hepatitis C, doctors most often use medications called direct acting antivirals, or DAAs. These drugs stop the virus from making copies of itself.

Your doctor will likely prescribe some combination of these drugs (glecaprevir, pibrentasvir, sofosbuvir, velpatasvir) for 8-12 weeks. Some pills combine two of these drugs into one pill.

But these medications may not be right for everyone because of cost, health issues, and other reasons. For example, DAAs may be problematic if you have hepatitis B, kidney disease, cirrhosis, HIV, liver cancer, or if you’re pregnant, have had a liver transplant, or have been treated for hepatitis C before. Still, even when your doctor has to add other drugs or adjust your dose, or prescribe it for a longer time, DAAs are very effective for hepatitis C in more than 90% of cases.

SOURCES:

CDC: “Hepatitis C Information.” 

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Goals and Benefits with HCV Treatment,” “Ledipasvir-Sofosbuvir (Harvoni).

Merck Manual: “Hepatitis C, Chronic,” “Hepatitis C, Acute,” “Overview of Chronic Hepatitis.”

RadiologyInfo.org: “Cirrhosis of the Liver.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability Of Economic Evaluation Studies: Is There A Generally Accepted Alternative Price Benchmark To The Wac Price?”

Reviewed by Jennifer Robinson on June 26, 2020

SOURCES:

CDC: “Hepatitis C Information.” 

Infohep.org: “Hepatitis C treatment factsheet: Harvoni (sofosbuvir + ledipasvir).”

Hepatitis C Online: “Goals and Benefits with HCV Treatment,” “Ledipasvir-Sofosbuvir (Harvoni).

Merck Manual: “Hepatitis C, Chronic,” “Hepatitis C, Acute,” “Overview of Chronic Hepatitis.”

RadiologyInfo.org: “Cirrhosis of the Liver.”

The Hepatitis Trust: “Harvoni.”

Treatment Action Group: “Harvoni Fact Sheet.”

University of Maryland School of Pharmacy: “Transferability Of Economic Evaluation Studies: Is There A Generally Accepted Alternative Price Benchmark To The Wac Price?”

Reviewed by Jennifer Robinson on June 26, 2020

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What is sustained virologic response (SVR) to hepatitis C?

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