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What is the APRI score?

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APRI is short for aspartate aminotransferase to platelet ratio index. It’s a way for doctors to measure how healthy your liver is when you have a liver disease.

Some health problems, including hepatitis, drinking too much alcohol, or a buildup of fat, can lead to inflammation in the liver and, after several years, liver disease. Scars can form on the organ. Doctors call this scarring fibrosis. When there’s too much fibrosis in the liver, scar tissue replaces healthy tissue. This leads to cirrhosis, a life-threatening condition that makes it hard for the liver to work well.

The APRI score measures the amount of fibrosis in the liver.

The APRI score is based on the amount of aspartate aminotransferase (AST) and platelets in your body. AST is an enzyme your liver creates. Platelets are a type of blood cell that help heal wounds and stop heavy bleeding.

Your doctor can check your AST and platelet levels with a blood test.

These two results help your doctor calculate your APRI score.

SOURCES:

Mayo Clinic: “Hepatitis C,” “Liver function tests,” “Cirrhosis,” “Liver transplantation for chronic hepatitis C: How common is it?”

Open Forum Infectious Diseases : “APRI Score as a Predictor of Significant Liver Fibrosis in Chronic Hepatitis B.”

Annals of Gastroenterology : “Liver fibrosis staging with combination of APRI and FIB-4 scoring systems in chronic hepatitis C as an alternative to transient elastography.”

National Library of Medicine: “Aspartate Transaminase to Platelet Ratio Index in Hepatitis C Virus and Schistosomiasis Coinfection,” “AST Test.”

American Red Cross: “Platelets and Thrombocytopenia.”

University of Washington (Hepatitis C): “AST to Platelet Ratio Index (APRI) Calculator.”

Medscape: “Role of AST to Platelet Ratio Index in the Detection of Liver Fibrosis in Patients with Recurrent Hepatitis C After Liver Transplantation.”

University of Michigan (Health Lab): “Alternatives to Liver Biopsy: When are other tests appropriate?”

University of California, San Francisco: “Platelet Count.”

Reviewed by Brunilda Nazario on June 26, 2020

SOURCES:

Mayo Clinic: “Hepatitis C,” “Liver function tests,” “Cirrhosis,” “Liver transplantation for chronic hepatitis C: How common is it?”

Open Forum Infectious Diseases : “APRI Score as a Predictor of Significant Liver Fibrosis in Chronic Hepatitis B.”

Annals of Gastroenterology : “Liver fibrosis staging with combination of APRI and FIB-4 scoring systems in chronic hepatitis C as an alternative to transient elastography.”

National Library of Medicine: “Aspartate Transaminase to Platelet Ratio Index in Hepatitis C Virus and Schistosomiasis Coinfection,” “AST Test.”

American Red Cross: “Platelets and Thrombocytopenia.”

University of Washington (Hepatitis C): “AST to Platelet Ratio Index (APRI) Calculator.”

Medscape: “Role of AST to Platelet Ratio Index in the Detection of Liver Fibrosis in Patients with Recurrent Hepatitis C After Liver Transplantation.”

University of Michigan (Health Lab): “Alternatives to Liver Biopsy: When are other tests appropriate?”

University of California, San Francisco: “Platelet Count.”

Reviewed by Brunilda Nazario on June 26, 2020

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