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How do non-nucleoside reverse transcriptase inhibitors (NNRTIs) help treat HIV and AIDS?

ANSWER

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are also called "non-nukes." NNRTIs bind to a specific protein so the HIV virus can't make copies of itself, similar to jamming a zipper.

SOURCES:

UpToDate: "Overview of antiretroviral agents used to treat HIV."

AIDSinfo Drug Database.

NIAID: "Treatment of HIV Infection."

American Academy of Family Physicians: "How to Take Your Medicines for HIV," "Medicines for People Who Are HIV Positive."

U.S. Dept. of Health and Human Services: "HIV and Its Treatment: What You Should Know," "Approved Medications to Treat HIV Infection."

Hammerl. Aug. 16, 2006. JAMA,

New Mexico AIDS Education and Training Center: "Taking Current Antiretroviral Drugs," "Other Antiretroviral Drugs in Development," "Immune Therapies in Development.

FDA: "First of a Kind in HIV Treatment."

AIDSinfo: "Fusion Inhibitor," "CCR5 Antagonist."

AIDS Treatment Data Network: "Drugs Used to Treat HIV."

Johns Hopkins Medicine: "Antiretroviral Therapy: Initial Regimen."

AIDS.gov: "Pre-Exposure Prophylaxis (PrEP)."

Reviewed by Jonathan E. Kaplan on June 29, 2019

SOURCES:

UpToDate: "Overview of antiretroviral agents used to treat HIV."

AIDSinfo Drug Database.

NIAID: "Treatment of HIV Infection."

American Academy of Family Physicians: "How to Take Your Medicines for HIV," "Medicines for People Who Are HIV Positive."

U.S. Dept. of Health and Human Services: "HIV and Its Treatment: What You Should Know," "Approved Medications to Treat HIV Infection."

Hammerl. Aug. 16, 2006. JAMA,

New Mexico AIDS Education and Training Center: "Taking Current Antiretroviral Drugs," "Other Antiretroviral Drugs in Development," "Immune Therapies in Development.

FDA: "First of a Kind in HIV Treatment."

AIDSinfo: "Fusion Inhibitor," "CCR5 Antagonist."

AIDS Treatment Data Network: "Drugs Used to Treat HIV."

Johns Hopkins Medicine: "Antiretroviral Therapy: Initial Regimen."

AIDS.gov: "Pre-Exposure Prophylaxis (PrEP)."

Reviewed by Jonathan E. Kaplan on June 29, 2019

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How do protease inhibitors (PIs) help treat HIV and AIDS?

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