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What biologic drugs are used to treat Crohn's disease?

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Biologic drugs such as infliximab (Remicade) or infliximab-dyyb (Inflectra) are often prescribed when a person with Crohn's disease does not respond to the standard treatments of 5 ASA-containing drugs, corticosteroids, and immunosuppressants. Infliximab is an antibody that attaches itself to the inflammation-promoting protein, tumor-necrosis factor-alpha (TNF-alpha). Other anti-TNF medications are adalimumab (Humira) and adalimumab-atto (Amjevita). These drugs are also used to treat other immune system disorders such as rheumatoid arthritis. Certolizumab (Cimzia) is another anti-TNF blocker approved to treat Crohn's disease.

There are other biologic alternatives to the anti-TNF blockers. For example, two drugs block alpha-4 integrin -- natalizumab (Tysabri) and vedolizumab (Entyvio). Ustekinumab (Stelara) works in another way by targeting other proteins, specifically IL-12 and IL-23.

SOURCES:

National Digestive Diseases Information Clearinghouse: "Crohn's Disease."

Crohn's & Colitis Foundation of America. "Crohn’s Diagnosis & Testing." "Crohn’s Disease Medication Options."

FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.”

Uptodate.com. "Overview of the medical management of severe or refractory Crohn disease in adults."

 

Reviewed by Minesh Khatri on October 19, 2017

SOURCES:

National Digestive Diseases Information Clearinghouse: "Crohn's Disease."

Crohn's & Colitis Foundation of America. "Crohn’s Diagnosis & Testing." "Crohn’s Disease Medication Options."

FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.”

Uptodate.com. "Overview of the medical management of severe or refractory Crohn disease in adults."

 

Reviewed by Minesh Khatri on October 19, 2017

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What other substances may be prescribed to treat Crohn's disease?

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