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How are biologic therapies used for inflammatory bowel disease?

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Biologic therapies are antibodies that target the action of certain other proteins that cause inflammation. Infliximab (Remicade) and infliximab-abda (Renflexis) or infliximab-dyyb (Inflectra), a biosimilar to Remicade, are drugs approved by the FDA to treat moderate to severe Crohn's disease when standard medications have been ineffective. They belong to a class of drugs known as anti-TNF agents. TNF (tumor necrosis factor) is produced by white blood cells and is believed to be responsible for promoting the tissue damage that occurs with Crohn's disease. Other anti-TNF agents approved for Crohn's disease are adalimumab (Humira), adalimumab-atto (Amjevita), a biosimilar to Humira, and certolizumab (Cimzia). An alternative to anti-TNF treatment for Crohn's disease are biologics that target integrin, two of which are natalizumab (Tysabri) and vedolizumab (Entyvio). Another drug, ustekinumab (Stelara), blocks IL-12 and IL-23. Adalimumab (Humira), adalimumab-atto (Amjevita), certolizumab (Cimzia), golimumab (Simponi, Simponi Aria), infliximab (Remicade), infliximab-abda (Renflexis), and infliximab-dyyb (Inflectra) are anti-TNF drugs currently approved by the FDA for ulcerative colitis.

SOURCE:  National Digestive Diseases Information Clearinghouse, National Institutes of Health. FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.” Crohn's & Colitis Foundation of America."Maintenance Therapy." "What is Crohn's Disease?" "What is Ulcerative Colitis?"  



Reviewed by Minesh Khatri on September 16, 2019

SOURCE:  National Digestive Diseases Information Clearinghouse, National Institutes of Health. FDA. “FDA approves Inflectra, a biosimilar to Remicade.” “FDA approves Amjevita, a biosimilar to Humira.” Crohn's & Colitis Foundation of America."Maintenance Therapy." "What is Crohn's Disease?" "What is Ulcerative Colitis?"  



Reviewed by Minesh Khatri on September 16, 2019

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