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    Biologics are prescription drugs made from living organisms. Your doctor may prescribe one to you if other treatments haven’t worked.

    Biologics work on your immune system. They target specific proteins in your body that cause inflammation.

    The FDA has approved these biologics to treat Crohn’s disease:

    • Adalimumab (Humira)
    • Adalimumab-atto (Amjevita), a biosimilar to adalimumab
    • Certolizumab pegol (Cimzia)
    • Infliximab (Remicade)
    • Infliximab-abda (Renflexis), a biosimilar to infliximab
    • Infliximab-dyyb (Inflectra), a biosimilar to infliximab
    • Natalizumab (Tysabri)
    • Vedolizumab (Entyvio)

    Adalimumab, adalimumab-atto, certolizumab pegol, infliximab, infliximab-abda, and infliximab-dyyb target a protein called TNF-alpha that's part of the inflammation process.

    Natalizumab blocks certain white blood cells that lead to inflammation.

    Vedolizumab stops the cells from crossing the blood vessels' walls into inflamed areas of your gastrointestinal tract.

    Adalimumab (Humira), Adalimumab-atto (Amjevita)

    These drugs may lessen symptoms of moderate to severe Crohn’s disease. It may also help keep them from coming back.

    How’s it given: You get it by a shot under the skin.

    What are the most common side effects?

    • Redness, swelling, itching, pain, rash, or bruising of the skin where you got the shot
    • Upper respiratory or sinus infections
    • Headache
    • Nausea

    What are some other potential side effects? All biologics share the potential for serious side effects, including infections like tuberculosis and sepsis. These drugs don't cause tuberculosis, but they may trigger it in people already exposed to the disease.

    A few people have gotten cancers like lymphoma.

    Certolizumab pegol (Cimzia)

    This drug reduces symptoms of moderate to severe Crohn’s disease. It also helps to keep them from returning.

    How’s it given: You get it by a shot under the skin.

    What are the most common side effects?

    • Rash
    • Swelling
    • Joint pain
    • Upper respiratory tract infection
    • Urinary tract infection

    What are other potential side effects? You may be more likely to get tuberculosis and sepsis.

    Your odds of getting other infections may be higher than most. Tell your doctor right away if you have an infection, or if you have a cough, fever, fatigue, or the flu. In rare cases, people have developed cancers like lymphoma.