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How do antidepressants treat IBS-D?

ANSWER

Medicines called tricyclic antidepressants can help reduce belly pain, particularly if you also have depression or anxiety. If you don’t have depression, you may still get prescribed these, but in smaller doses. Your doctor can let you know if they're right for you.

SOURCES:

Canavan, C., Clinical Epidemiology, February 2014, “The epidemiology of irritable bowel syndrome.”

IBS in America Survey, American Gastroenterological Association.

Current and future treatments for IBS-D, Mayo Clinic.

Lewis, J.H., Expert Review of Gastroenterology and Hepatology, February 2010,  “Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.”

Ischemic colitis, Mayo Clinic.

Irritable bowel syndrome: Treatment and drugs, Mayo Clinic.

Grover, M., Clinical Gastroenterology and Hepatology, June 2014, “Ramosetron in Irritable Bowel Syndrome With Diarrhea: New Hope or the Same Old Story?”

Chang, L., Gastroenterology and Hepatology, September 2010, “An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium.”

FDA approves two therapies to treat IBS-D, U.S. Food and Drug Administration.

Disease management: Irritable Bowel Syndrome, Cleveland Clinic Center for Continuing Education.

Aragon, G., Gastroenterology and Hepatology, January 2010, “Probiotic therapy for irritable bowel syndrome.”

Walters, J., Therapeutic Advances in Gastroenterology, November 2010, " Managing bile acid diarrhea.”

Overview of Biliary Function, Merck Manual.

Annahazi, A., World Journal of Gastroenterology, May 28, 2014, "Role of antispasmodics in the treatment of irritable bowel syndrome.”

Philpott, H., Asia Pacific Allergy, April 2011, “Irritable bowel syndrome - An inflammatory disease involving mast cells.”

Peyton, L., Pharmacy & Therapeutics, August 2014, “Irritable Bowel Syndrome: Current and Emerging Treatments.”

Reviewed by Minesh Khatri on February 15, 2020

SOURCES:

Canavan, C., Clinical Epidemiology, February 2014, “The epidemiology of irritable bowel syndrome.”

IBS in America Survey, American Gastroenterological Association.

Current and future treatments for IBS-D, Mayo Clinic.

Lewis, J.H., Expert Review of Gastroenterology and Hepatology, February 2010,  “Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.”

Ischemic colitis, Mayo Clinic.

Irritable bowel syndrome: Treatment and drugs, Mayo Clinic.

Grover, M., Clinical Gastroenterology and Hepatology, June 2014, “Ramosetron in Irritable Bowel Syndrome With Diarrhea: New Hope or the Same Old Story?”

Chang, L., Gastroenterology and Hepatology, September 2010, “An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium.”

FDA approves two therapies to treat IBS-D, U.S. Food and Drug Administration.

Disease management: Irritable Bowel Syndrome, Cleveland Clinic Center for Continuing Education.

Aragon, G., Gastroenterology and Hepatology, January 2010, “Probiotic therapy for irritable bowel syndrome.”

Walters, J., Therapeutic Advances in Gastroenterology, November 2010, " Managing bile acid diarrhea.”

Overview of Biliary Function, Merck Manual.

Annahazi, A., World Journal of Gastroenterology, May 28, 2014, "Role of antispasmodics in the treatment of irritable bowel syndrome.”

Philpott, H., Asia Pacific Allergy, April 2011, “Irritable bowel syndrome - An inflammatory disease involving mast cells.”

Peyton, L., Pharmacy & Therapeutics, August 2014, “Irritable Bowel Syndrome: Current and Emerging Treatments.”

Reviewed by Minesh Khatri on February 15, 2020

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How do antispasmodics help treat irritable bowel syndrome with diarrhea (IBS-D)?

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