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What causes antisperm antibodies?

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In men, an infection in their prostate or an injury to their testicles can set off an immune response when the sperm comes in contact with blood. This can also happen after a testicle surgery like a vasectomy.

Women’s bodies can make antisperm antibodies if they have an allergic reaction to semen. Antibodies in a woman’s vagina kill the sperm. That’s rare, and doctors don’t know exactly why it happens.

SOURCES:

University of Utah Health: “Evaluating Male Fertility.”

S. Adam Ramin, MD, Providence Saint John's Health Center, Santa Monica, CA; founder and medical director, Urology Cancer Specialists, Los Angeles.

UpToDate: “Causes of male infertility.”

Actas Urológicas Espaõlas: “Antisperm antibodies and fertility association.”

International Journal of Fertility: “Treatment of infertility caused by antisperm antibodies.”

Methods in Molecular Biology: “Methods for direct and indirect antisperm antibody testing.”

Reproductive Medicine and Biology: “Diagnosis and treatment of immunologically infertile males with antisperm antibodies.”

National Institute for Health and Care Excellence: “Fertility: Do Not Do Recommendation.”

Middle Eastern Fertility Society Journal: “Zinc sulfate treatment of secondary male infertility associated with positive serum and seminal plasma anti-sperm antibody test.”

American Pregnancy Association: “Intrauterine Insemination.”

International Journal of Gynecology & Obstetrics: “Intrauterine insemination as a treatment of infertility in women with antisperm antibodies.”

Reviewed by Kecia Gaither on January 30, 2018

SOURCES:

University of Utah Health: “Evaluating Male Fertility.”

S. Adam Ramin, MD, Providence Saint John's Health Center, Santa Monica, CA; founder and medical director, Urology Cancer Specialists, Los Angeles.

UpToDate: “Causes of male infertility.”

Actas Urológicas Espaõlas: “Antisperm antibodies and fertility association.”

International Journal of Fertility: “Treatment of infertility caused by antisperm antibodies.”

Methods in Molecular Biology: “Methods for direct and indirect antisperm antibody testing.”

Reproductive Medicine and Biology: “Diagnosis and treatment of immunologically infertile males with antisperm antibodies.”

National Institute for Health and Care Excellence: “Fertility: Do Not Do Recommendation.”

Middle Eastern Fertility Society Journal: “Zinc sulfate treatment of secondary male infertility associated with positive serum and seminal plasma anti-sperm antibody test.”

American Pregnancy Association: “Intrauterine Insemination.”

International Journal of Gynecology & Obstetrics: “Intrauterine insemination as a treatment of infertility in women with antisperm antibodies.”

Reviewed by Kecia Gaither on January 30, 2018

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When should you get tested for antisperm antibodies?

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