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Should my doctor run an EKG test before taking drugs for non-small-cell lung cancer?

ANSWER

Before you take these drugs, your doctor should run an EKG to test your heart health. ALK inhibitors have been linked to changes in the heartbeat or heart rate that aren’t explained by other health problems or medications.

SOURCES:

Roswell Park Cancer Institute: "Targeting Anaplastic Lymphoma Kinase (ALK) Gene in Non-Small Cell Lung Cancer."

My Cancer Genome: "ALK in Non-Small Cell Lung Cancer (NSCLC)."

Genetics Home Reference: "ALK."

Lung Cancer Foundation of America: "What Targeted Therapies Are Currently Available?"

Memorial Sloan Kettering Cancer Center: "Genomic Testing."

UpToDate: Anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer.”

American Cancer Society: "Treatment choices by stage for non-small cell lung cancer."

American Cancer Society: "Targeted therapies for non-small cell lung cancer."

Bang, Y.J. October 2012. Archives of Pathology & Laboratory Medicine,

Korpanty, G.J. , 2014. Frontiers in Oncology

UpToDate: “Patient information: Non-small cell lung cancer treatment; stage IV cancer (Beyond the Basics)."

Lab Tests Online. "ALK Mutation (Gene Rearrangement)." 

American Cancer Society: “Cancer Facts & Figures 2015.”

American Cancer Society: “Lung Cancer (Non-Small Cell).”

Reviewed by Laura J. Martin on June 06, 2018

SOURCES:

Roswell Park Cancer Institute: "Targeting Anaplastic Lymphoma Kinase (ALK) Gene in Non-Small Cell Lung Cancer."

My Cancer Genome: "ALK in Non-Small Cell Lung Cancer (NSCLC)."

Genetics Home Reference: "ALK."

Lung Cancer Foundation of America: "What Targeted Therapies Are Currently Available?"

Memorial Sloan Kettering Cancer Center: "Genomic Testing."

UpToDate: Anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer.”

American Cancer Society: "Treatment choices by stage for non-small cell lung cancer."

American Cancer Society: "Targeted therapies for non-small cell lung cancer."

Bang, Y.J. October 2012. Archives of Pathology & Laboratory Medicine,

Korpanty, G.J. , 2014. Frontiers in Oncology

UpToDate: “Patient information: Non-small cell lung cancer treatment; stage IV cancer (Beyond the Basics)."

Lab Tests Online. "ALK Mutation (Gene Rearrangement)." 

American Cancer Society: “Cancer Facts & Figures 2015.”

American Cancer Society: “Lung Cancer (Non-Small Cell).”

Reviewed by Laura J. Martin on June 06, 2018

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Is chemotherapy used to treat non-small-cell lung cancer?

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