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What drugs attack ALK gene rearrangement in lung cancer?

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The drugs alectinib (Alecensa), certinib (Zykadia) and crizotinib (Xalkori) have been found to attack a certain molecule, an ALK gene rearrangement, seen in some lung cancers. 

Several of these drugs are also used for tumors that have ROS1 gene changes.

 Dabrafenib (Tafinlar) and Trametinib (Mekinist) target certain proteins in tumors that have changes in the BRAF gene.

It is now common for patients to be tested to determine if these drugs can effectively fight their type of lung cancer.

SOURCES: 

National Cancer Institute. 

National Institutes of Health. 

WebMD Medical Reference from the American College of Physicians: “Section 12 VIII Lung Cancer.”

News release, FDA.

American Cancer Society.

American Lung Association. 

Reviewed by Carol DerSarkissian on February 05, 2019

SOURCES: 

National Cancer Institute. 

National Institutes of Health. 

WebMD Medical Reference from the American College of Physicians: “Section 12 VIII Lung Cancer.”

News release, FDA.

American Cancer Society.

American Lung Association. 

Reviewed by Carol DerSarkissian on February 05, 2019

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