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What should you know about chemotherapy for stage IV lung cancer with ALK rearrangement?

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Your doctor might start you on chemotherapy before you get tested for the ALK rearrangement. If you’re ALK-positive and already on chemo, some experts say you should stick with it for several cycles – as long as you can handle it and the cancer doesn’t spread. If the cancer does spread, your doctor may switch you to crizotinib (Xalkori).

SOURCES:

Roswell Park Cancer Institute: "Targeting Anaplastic Lymphoma Kinase (ALK) Gene in Non-Small Cell Lung Cancer."

My Cancer Genome: "ALK in Non-Small Cell Lung Cancer (NSCLC)."

Genetics Home Reference: "ALK."

Lung Cancer Foundation of America: "What Targeted Therapies Are Currently Available?"

Memorial Sloan Kettering Cancer Center: "Genomic Testing."

UpToDate: Anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer.”

American Cancer Society: "Treatment choices by stage for non-small cell lung cancer."

American Cancer Society: "Targeted therapies for non-small cell lung cancer."

Bang, Y.J. October 2012. Archives of Pathology & Laboratory Medicine,

Korpanty, G.J. , 2014. Frontiers in Oncology

UpToDate: “Patient information: Non-small cell lung cancer treatment; stage IV cancer (Beyond the Basics)."

Lab Tests Online. "ALK Mutation (Gene Rearrangement)." 

American Cancer Society: “Cancer Facts & Figures 2015.”

American Cancer Society: “Lung Cancer (Non-Small Cell).”

Reviewed by Laura J. Martin on June 06, 2018

SOURCES:

Roswell Park Cancer Institute: "Targeting Anaplastic Lymphoma Kinase (ALK) Gene in Non-Small Cell Lung Cancer."

My Cancer Genome: "ALK in Non-Small Cell Lung Cancer (NSCLC)."

Genetics Home Reference: "ALK."

Lung Cancer Foundation of America: "What Targeted Therapies Are Currently Available?"

Memorial Sloan Kettering Cancer Center: "Genomic Testing."

UpToDate: Anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer.”

American Cancer Society: "Treatment choices by stage for non-small cell lung cancer."

American Cancer Society: "Targeted therapies for non-small cell lung cancer."

Bang, Y.J. October 2012. Archives of Pathology & Laboratory Medicine,

Korpanty, G.J. , 2014. Frontiers in Oncology

UpToDate: “Patient information: Non-small cell lung cancer treatment; stage IV cancer (Beyond the Basics)."

Lab Tests Online. "ALK Mutation (Gene Rearrangement)." 

American Cancer Society: “Cancer Facts & Figures 2015.”

American Cancer Society: “Lung Cancer (Non-Small Cell).”

Reviewed by Laura J. Martin on June 06, 2018

NEXT QUESTION:

What other treatments might you need for stage IV lung cancer with ALK rearrangement?

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