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Which drugs treat small-cell lung cancer (SCLC)

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Right now, there aren’t any FDA-approved immunotherapy drugs for SCLC. To receive this green light, drugs have to go through four phases of clinical trials. These studies decide if a treatment is safe and if it works.

Most immunotherapy drugs for SCLC are in the first or second phase. That means researchers still need to do trials on larger groups for longer periods of time. That’s how they figure out what the long-term side effects of the drugs might be.

SOURCES:

The Oncologist: “The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer.”

American Cancer Society: “Small Cell Lung Cancer Treatment,” “What Is Immunotherapy?”

Meaghan L. Khan, MD, oncologist, Baylor Scott & White Healthcare.

Antonio Giordano, MD, PhD, director, Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University; professor of pathology, University of Sienna, Italy.

Scott Antonia, MD, PhD, chair, department of thoracic oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; professor, oncologic Sciences, University of South Florida College of Medicine, Tampa, FL.

NIH: “FAQ: ClinicalTrials.gov - Clinical Trial Phases.”

National Comprehensive Cancer Network: “About NCCN.”

Merck: “Frequently Asked Questions about pembrolizumab Expanded Access Program.”

Clinical Trials.gov: “SC16LD6.5 in Recurrent Small Cell Lung Cancer.”

OncoMed Pharmaceuticals: “Development Pipeline.”

Clinical Cancer Research: “Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency.”

Abstract presented at the 2016 ASCO Annual Meeting: “Safety and efficacy of single-agent rovalpituzumab tesirine (SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody-drug conjugate (ADC) in recurrent or refractory small cell lung cancer (SCLC).”

Reviewed by Laura J. Martin on December 28, 2016

SOURCES:

The Oncologist: “The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer.”

American Cancer Society: “Small Cell Lung Cancer Treatment,” “What Is Immunotherapy?”

Meaghan L. Khan, MD, oncologist, Baylor Scott & White Healthcare.

Antonio Giordano, MD, PhD, director, Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University; professor of pathology, University of Sienna, Italy.

Scott Antonia, MD, PhD, chair, department of thoracic oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; professor, oncologic Sciences, University of South Florida College of Medicine, Tampa, FL.

NIH: “FAQ: ClinicalTrials.gov - Clinical Trial Phases.”

National Comprehensive Cancer Network: “About NCCN.”

Merck: “Frequently Asked Questions about pembrolizumab Expanded Access Program.”

Clinical Trials.gov: “SC16LD6.5 in Recurrent Small Cell Lung Cancer.”

OncoMed Pharmaceuticals: “Development Pipeline.”

Clinical Cancer Research: “Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency.”

Abstract presented at the 2016 ASCO Annual Meeting: “Safety and efficacy of single-agent rovalpituzumab tesirine (SC16LD6.5), a delta-like protein 3 (DLL3)-targeted antibody-drug conjugate (ADC) in recurrent or refractory small cell lung cancer (SCLC).”

Reviewed by Laura J. Martin on December 28, 2016

NEXT QUESTION:

Can doctors prescribe immunotherapies for small-cell lung cancer (SCLC)?

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