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Which antibiotics are used to treat mycobacterium avium complex (MAC) disease?

ANSWER

Doctors treat mycobacterium avium complex (MAC) disease, the most common NTM lung infection, with a combination of three antibiotics:

  • Either azithromycin and clarithromycin
  • Ethambutol
  • Rifampin

SOURCES:

National Organization for Rare Disorders: “Nontuberculous Mycobacterial Lung Disease.”

Tuberculosis and Respiratory Diseases : “Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease: Clinicians' Perspectives.”

American Lung Association: “Diagnosing and Treating NTM Pulmonary Disease.”

American Journal of Respiratory and Critical Care Medicine : “An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases.”

Morbidity and Mortality Weekly Report : “Recommendations on Prophylaxis and Therapy for Disseminated Mycobacterium Avium Complex for Adults and Adolescents Infected With Human Immunodeficiency Virus.”

American Thoracic Society: “Palliative Care for People With Respiratory Disease or Critical Illness.”

UpToDate: “Treatment of Mycobacterium avium complex lung infection in adultsTreatment of Myobacterium avium lung infection in adults,” “Myobacterium avium complex (MAC) in HIV-infected patients.”complex (MAC) infections in HIV-infected patients."

NTM Info & Research: “Currently Recruiting.”

Reviewed by Neha Pathak on June 02, 2017

SOURCES:

National Organization for Rare Disorders: “Nontuberculous Mycobacterial Lung Disease.”

Tuberculosis and Respiratory Diseases : “Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease: Clinicians' Perspectives.”

American Lung Association: “Diagnosing and Treating NTM Pulmonary Disease.”

American Journal of Respiratory and Critical Care Medicine : “An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases.”

Morbidity and Mortality Weekly Report : “Recommendations on Prophylaxis and Therapy for Disseminated Mycobacterium Avium Complex for Adults and Adolescents Infected With Human Immunodeficiency Virus.”

American Thoracic Society: “Palliative Care for People With Respiratory Disease or Critical Illness.”

UpToDate: “Treatment of Mycobacterium avium complex lung infection in adultsTreatment of Myobacterium avium lung infection in adults,” “Myobacterium avium complex (MAC) in HIV-infected patients.”complex (MAC) infections in HIV-infected patients."

NTM Info & Research: “Currently Recruiting.”

Reviewed by Neha Pathak on June 02, 2017

NEXT QUESTION:

What are side effects from medications that treat nontuberculous mycobacterial lung disease (NTM)?

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