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What are the uses and limitations of an anti-dsDNA for lupus?

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Anti-dsDNA is a protein directed against double-stranded DNA. DNA is the material that makes up the body's genetic code. Between 75% and 90% of people with lupus have a positive anti-dsDNA test. Also, the test is very specific for lupus. Therefore, a positive test can be useful in confirming a diagnosis. For many people, the titer, or level, of the antibodies rises as the disease becomes more active. So, doctors can also use it to help measure disease activity. Also, the presence of anti-dsDNA indicates a greater risk of lupus nephritis, a kidney inflammation that occurs with lupus. So a positive test can alert doctors to the need to monitor the kidneys. Up to 25% of people with lupus have a negative test. So, a negative test doesn't mean a person doesn't have lupus.

From: Lab Tests for Lupus WebMD Medical Reference

SOURCES:

Robert Wood Johnson University Hospital: "Systemic Lupus Erythematosus (Lupus)."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Lupus: A Patient Care Guide for Nurses and Other Health Professionals, 3rd Edition."

Lupus Foundation of America: "Lab Tests."

NYU School of Medicine: "Neonatal Lupus."

Lupus Alliance of America: "Laboratory Tests for Lupus."

Children's Hospital of Pittsburgh: "Diagnosing Arthritis and Other Rheumatic Diseases."

Sjogren's Syndrome Foundation.

Reviewed by Jennifer Robinson on October 23, 2017

SOURCES:

Robert Wood Johnson University Hospital: "Systemic Lupus Erythematosus (Lupus)."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Lupus: A Patient Care Guide for Nurses and Other Health Professionals, 3rd Edition."

Lupus Foundation of America: "Lab Tests."

NYU School of Medicine: "Neonatal Lupus."

Lupus Alliance of America: "Laboratory Tests for Lupus."

Children's Hospital of Pittsburgh: "Diagnosing Arthritis and Other Rheumatic Diseases."

Sjogren's Syndrome Foundation.

Reviewed by Jennifer Robinson on October 23, 2017

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What are the uses and limitations of an anti-Ro(SSA) and anti-La(SSB) test for lupus?

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