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What are the uses and limitations of an anti-Sm test for lupus?

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Anti-Sm is an antibody directed against Sm, a specific protein found in the cell nucleus. The protein is found in up to 30% of people with lupus. It's rarely found in people without lupus. So a positive test can help confirm a lupus diagnosis. Keep in mind, up to only 30% of people with lupus have a positive anti-Sm test. So relying on an anti-Sm result alone would miss a large majority of people with lupus.

From: Lab Tests for Lupus WebMD Medical Reference

SOURCES:

Robert Wood Johnson University Hospital: "Systemic Lupus Erythematosus (Lupus)."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Lupus: A Patient Care Guide for Nurses and Other Health Professionals, 3rd Edition."

Lupus Foundation of America: "Lab Tests."

NYU School of Medicine: "Neonatal Lupus."

Lupus Alliance of America: "Laboratory Tests for Lupus."

Children's Hospital of Pittsburgh: "Diagnosing Arthritis and Other Rheumatic Diseases."

Sjogren's Syndrome Foundation.

Reviewed by Jennifer Robinson on October 23, 2017

SOURCES:

Robert Wood Johnson University Hospital: "Systemic Lupus Erythematosus (Lupus)."

National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Lupus: A Patient Care Guide for Nurses and Other Health Professionals, 3rd Edition."

Lupus Foundation of America: "Lab Tests."

NYU School of Medicine: "Neonatal Lupus."

Lupus Alliance of America: "Laboratory Tests for Lupus."

Children's Hospital of Pittsburgh: "Diagnosing Arthritis and Other Rheumatic Diseases."

Sjogren's Syndrome Foundation.

Reviewed by Jennifer Robinson on October 23, 2017

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What are the uses and limitations of an anti-dsDNA for lupus?

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