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What are BRAF inhibitors as a type of targeted therapy for melanoma?

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“Targeted therapies” shrink melanoma cells without harming healthy cells. Some target a gene change called “BRAF” that makes melanomas grow. Your doctor may call these drugs “BRAF inhibitors.” They shrink tumors and help some people live longer.

SOURCES:

American Academy of Dermatology: "Imiquimod: FAQS," "Imiquimod: Overview."

American Cancer Society: "Chemotherapy for melanoma skin cancer," "How is melanoma skin cancer treated?" "Immunotherapy for melanoma skin cancer," "Radiation therapy for melanoma skin cancer," "Surgery for melanoma skin cancer," "Targeted therapy for melanoma skin cancer," "Treatment of Melanoma Skin Cancer by Stage."

Japanese Journal of Clinical Oncology : "Complex Combination Biochemotherapy Regimen in Advanced Metastatic Melanoma in a Non-intensive Care Unit: Toxicity or Benefit?"

Cutis: "Topical Imiquimod Clears Melanoma."

Cancer Journal: "Surgery for Distant Melanoma Metastasis."

MD Anderson Cancer Center: "Melanoma Treatment."

National Cancer Institute: "Melanoma Treatment (PDQ)."

Journal of the American Academy of Dermatology : "100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: Results of a case series."

Cochrane : "Interventions for treatment of melanoma in situ, including lentigo maligna."

UpToDate: "Patient information: Melanoma treatment; advanced or metastatic melanoma (Beyond the Basics)."

ClinicalTrials.gov: "Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma."

Reviewed by Stephanie S. Gardner on November 14, 2018

SOURCES:

American Academy of Dermatology: "Imiquimod: FAQS," "Imiquimod: Overview."

American Cancer Society: "Chemotherapy for melanoma skin cancer," "How is melanoma skin cancer treated?" "Immunotherapy for melanoma skin cancer," "Radiation therapy for melanoma skin cancer," "Surgery for melanoma skin cancer," "Targeted therapy for melanoma skin cancer," "Treatment of Melanoma Skin Cancer by Stage."

Japanese Journal of Clinical Oncology : "Complex Combination Biochemotherapy Regimen in Advanced Metastatic Melanoma in a Non-intensive Care Unit: Toxicity or Benefit?"

Cutis: "Topical Imiquimod Clears Melanoma."

Cancer Journal: "Surgery for Distant Melanoma Metastasis."

MD Anderson Cancer Center: "Melanoma Treatment."

National Cancer Institute: "Melanoma Treatment (PDQ)."

Journal of the American Academy of Dermatology : "100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: Results of a case series."

Cochrane : "Interventions for treatment of melanoma in situ, including lentigo maligna."

UpToDate: "Patient information: Melanoma treatment; advanced or metastatic melanoma (Beyond the Basics)."

ClinicalTrials.gov: "Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanoma."

Reviewed by Stephanie S. Gardner on November 14, 2018

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What are side effects of targeted therapies for treating metastatic melanoma?

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