PREVIOUS QUESTION:

 

NEXT QUESTION:

 

What drugs are used to help treat metastatic melanoma?

ANSWER

Some drugs attack a gene called BRAF. About half the people who have melanoma have mutations affecting this gene, which helps cancer cells grow. If you have a tumor with BRAF, these drugs may shrink it and extend your life. They include:

Other drugs block an enzyme called MEK. This enzyme sends abnormal signals to the body, causing cancer. These drugs, working in combination with a BRAF inhibitor to attack cancer cells, seem to shrink tumors for a longer period of time:

  • Dabrafenib (Tafinlar)
  • Encorafenib (Braftovi)
  • Vemurafenib (Zelboraf)
  • Binimetinib (Mektovi)
  • Cobimetinib (Cotellic)
  • Trametinib (Mekinist)

From: Metastatic Melanoma WebMD Medical Reference

SOURCES:

American Cancer Society: "Melanoma Skin Cancer Overview," "Treatment of melanoma sin cancer by stage,” "Targeted therapy for melanoma skin cancer."

Cancer Research UK: "Living with Advanced Melanoma."

FDA: "FDA approves Yervoy to reduce the risk of melanoma returning after surgery," "FDA approves Cotellic as part of combination treatment for advanced melanoma."

Macmillan Cancer Support: "Symptoms of advanced melanoma."

National Cancer Institute: "What You Need to Know About Melanoma and Other Skin Cancers."

Skin Cancer Foundation: "Melanoma."

UCSF Medical Center: "Melanoma."

Medscape: “Some Melanoma Patients Living for up to 10 Years After Ipilimumab.”

UpToDate: "Melanoma treatment; advanced or metastatic melanoma (Beyond the Basics)."

American Cancer Society. 

News release, FDA.

Reviewed by Laura J. Martin on August 19, 2018

SOURCES:

American Cancer Society: "Melanoma Skin Cancer Overview," "Treatment of melanoma sin cancer by stage,” "Targeted therapy for melanoma skin cancer."

Cancer Research UK: "Living with Advanced Melanoma."

FDA: "FDA approves Yervoy to reduce the risk of melanoma returning after surgery," "FDA approves Cotellic as part of combination treatment for advanced melanoma."

Macmillan Cancer Support: "Symptoms of advanced melanoma."

National Cancer Institute: "What You Need to Know About Melanoma and Other Skin Cancers."

Skin Cancer Foundation: "Melanoma."

UCSF Medical Center: "Melanoma."

Medscape: “Some Melanoma Patients Living for up to 10 Years After Ipilimumab.”

UpToDate: "Melanoma treatment; advanced or metastatic melanoma (Beyond the Basics)."

American Cancer Society. 

News release, FDA.

Reviewed by Laura J. Martin on August 19, 2018

NEXT QUESTION:

What can you do to take care of yourself if you have metastatic melanoma?

WAS THIS ANSWER HELPFUL

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

    This tool does not provide medical advice. See additional information.

    Other Answers On: