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What are the side effects of 5-alpha reductase inhibitors (5-ARIs) used to treat benign prostatic hyperplasia (BPH)?

ANSWER

These are drugs to treat BPH, also called enlarged prostate. They can work especially well for men with very large prostates. But they can cause side effects that include:

  • Erectile dysfunction
  • Lower sex drive
  • Retrograde ejaculation, when you semen goes backward into your bladder

Some of these issues may get better as your body gets used to the medicine.

SOURCES:

PubMed: “Various treatment options for benign prostatic hyperplasia: A current update.”

Mayo Clinic: “Benign Prostatic Hyperplasia (BPH).”

Johns Hopkins: “Benign Prostatic Hyperplasia.”

Urology Care Foundation: “Benign Prostatic Hyperplasia (BPH).”

Merck, “Highlights of Prescribing Information: Propecia.”

American Academy of Ophthalmology: “Alpha-Blocker Patient Advisory ASCRS and AAO Information Statement.”

NHS: “Treating Benign Prostate Enlargement.”

NIH, National Institutes of Diabetes and Digestive and Kidney Diseases: “Prostate Enlargement: Benign Prostatic Hyperplasia.”

Medscape: “Benign Prostatic Hypertrophy Treatment & Management.”

FDA: “Questions and Answers for Cialis (tadalafil).

Reviewed by Carmelita Swiner on November 18, 2020

SOURCES:

PubMed: “Various treatment options for benign prostatic hyperplasia: A current update.”

Mayo Clinic: “Benign Prostatic Hyperplasia (BPH).”

Johns Hopkins: “Benign Prostatic Hyperplasia.”

Urology Care Foundation: “Benign Prostatic Hyperplasia (BPH).”

Merck, “Highlights of Prescribing Information: Propecia.”

American Academy of Ophthalmology: “Alpha-Blocker Patient Advisory ASCRS and AAO Information Statement.”

NHS: “Treating Benign Prostate Enlargement.”

NIH, National Institutes of Diabetes and Digestive and Kidney Diseases: “Prostate Enlargement: Benign Prostatic Hyperplasia.”

Medscape: “Benign Prostatic Hypertrophy Treatment & Management.”

FDA: “Questions and Answers for Cialis (tadalafil).

Reviewed by Carmelita Swiner on November 18, 2020

NEXT QUESTION:

What are the two main 5-alpha reductase inhibitors (5-ARIs) for benign prostatic hyperplasia (BPH)?

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