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What are the cons to using estrogen replacement therapy vaginal suppositories, rings, and creams?

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Suppositories and rings with low doses of estrogen only help with vaginal symptoms of surgical menopause. They won't help with other symptoms like hot flashes. And while higher dose suppositories, rings, and creams could help with these symptoms, they may expose you to the same risks as other types of estrogen therapy -- including a higher risk of stroke and cancer. Most doctors don't recommend long-term vaginal estrogen therapy to women who still have their uterus, because it may make endometrial cancer more likely.

SOURCES:

ACP Medicine web site: "Menopause."

Canonico M et al, Circulation, Feb. 20, 2007; vol 115: pp 840-845.

MedicineNet web site: "Hormone Creams: Safe and Effective?"

National Cancer Institute web site: "How to Deal with Surgical Menopause."

National Institutes of Health web site: "Facts About Menopausal Hormone Therapy."

National Institutes of Health Medline Plus web site: "Estrogen," "Estrogen Vaginal," "Estradiol Topical," "Estradiol Transdermal."

  Practice Committee of the American Society for Reproductive Medicine, Fertility and Sterility, November 2006; vol 86: pp S75-S88.

National Women's Health information Center: "Menopause and Menopause Treatments." WebMD Medical Reference: "Estrogen Replacement Therapy," "Low Dose Estrogen for Dryness and Atrophy."

Reviewed by Nivin Todd on October 31, 2019

SOURCES:

ACP Medicine web site: "Menopause."

Canonico M et al, Circulation, Feb. 20, 2007; vol 115: pp 840-845.

MedicineNet web site: "Hormone Creams: Safe and Effective?"

National Cancer Institute web site: "How to Deal with Surgical Menopause."

National Institutes of Health web site: "Facts About Menopausal Hormone Therapy."

National Institutes of Health Medline Plus web site: "Estrogen," "Estrogen Vaginal," "Estradiol Topical," "Estradiol Transdermal."

  Practice Committee of the American Society for Reproductive Medicine, Fertility and Sterility, November 2006; vol 86: pp S75-S88.

National Women's Health information Center: "Menopause and Menopause Treatments." WebMD Medical Reference: "Estrogen Replacement Therapy," "Low Dose Estrogen for Dryness and Atrophy."

Reviewed by Nivin Todd on October 31, 2019

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How long will I have to take hormone replacement therapy?

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