What Is Ubrelvy (Ubrogepant)?

Medically Reviewed by Poonam Sachdev on November 08, 2021

Used to treat the symptoms of migraine headaches, the medication Ubrelvy — also known as ubrogepant — blocks the calcitonin gene-related peptide (CGRP) protein, which is believed to play a major role in causing the pain and inflammation caused by migraine attacks. Unlike older migraine medicines, Ubrelvy is the first pill to directly do this.

While Ubrelvy doesn't prevent migraine attacks or reduce the number of headaches you have, the prescription medication — available in pill form — has proven effective among migraine sufferers.

How Does Ubrelvy Work?

A relatively new drug, Ubrelvy works differently than previous migraine medications by directly stopping CGRP, a protein believed to be a major factor in triggering migraines, causing pain and inflammation.

As a CGRP antagonist, Ubrelvy can treat most symptoms of migraines, including throbbing pain, nausea, and light and sound sensitivity. It does this by blocking the protein from binding to your nerve endings.

How Do I Take Ubrelvy?

Prescribed by a doctor, Ubrelvy is a pill that can be taken orally at any time throughout the day with or without food. This medication has two different dosage strengths. Your doctor will determine which one you'll need to treat your migraines and whether you should take a second dose. They'll also determine how many times in a month you can safely take Ubrelvy for migraine treatment.

Does Ubrelvy Have Side Effects?

As with any migraine medication, Ubrelvy can have side effects, which may include:

  • Drowsiness
  • Nausea or vomiting
  • Dry mouth
  • Allergic reactions

Those who eat grapefruit shouldn't take a second dose of Ubrelvy within 24 hours of the first dose. Caution should also be practiced when taking Ubrelvy with other medications.

It's important to talk to your doctor if you have any questions about this medication, especially if you're experiencing side effects. As with any medicine, it's important to weigh the benefits of taking Ubrelvy against any adverse reactions.

Show Sources


Medline Plus: “Ubrogepant.” "How Does Ubrelvy Work?", “Quickly Stop a Migraine in its Tracks.”  

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