Medications used to prevent migraine with aura include those typically used for the more common form of migraine, such as antiseizure medications like topiramate, antidepressants such as amitriptyline, and CGRP inhibitors, like erenumab (Aimovig) or fremanezumab (Ajovy).
The FDA approved the transcutaneous magnetic stimulator by eNeura or SpringTMS that can be applied to the back of the head at the onset of the aura to help prevent the headache. There is also a noninvasive vagus nerve stimulator called gammaCore. When placed over the vagus nerve in the neck, it releases a mild electrical stimulation to the nerve's fibers to relieve pain. Similarly, Cefaly uses transcutaneous supraorbital nerve stimulation and is worn as a headband on the forehead and turned on daily for 20 minutes to prevent migraine from developing.