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How can botulinum toxin (Botox) help prevent chronic migraine?

ANSWER

Long used to fill wrinkles, this nerve toxin has been found to stave off chronic migraines. It prevents a pain network in your brain from turning on.

But it's only approved for people who have headaches at least 15 days each month. The more frequent your migraines, the better Botox seems to help. You may need several treatments before it starts to work.

SOURCES:

The Migraine Trust: "Preventive medicines."

American Family Physician : "Medications for Migraine Prophylaxis."

Progress in Cardiovascular Nursing : "Cardiovascular Effects of Migraine Therapy."

Harvard Health Publishing: "Migraines: Stop them before they start."

Headache : "Beta-Blockers for Migraine."

Medscape: "verapamil (Rx)."

National Headache Foundation: "Calcium Channel Blockers."

Mayo Clinic: "Migraine treatment: Can antidepressants help?"

PubChem Open Chemistry Database: "Amitriptyline," "Noritriptyline."

Consumer Reports : "Amitriptyline May Help Reduce Migraine Frequency."

American Migraine Foundation: "Botox for Migraine," "Calcitonin Gene-Related Peptide Targeted Therapy for Migraine."

NHS Choices: "Migraine - Prevention."

UpToDate: "Chronic Migraine."

Reviewed by Melinda Ratini on May 20, 2018

SOURCES:

The Migraine Trust: "Preventive medicines."

American Family Physician : "Medications for Migraine Prophylaxis."

Progress in Cardiovascular Nursing : "Cardiovascular Effects of Migraine Therapy."

Harvard Health Publishing: "Migraines: Stop them before they start."

Headache : "Beta-Blockers for Migraine."

Medscape: "verapamil (Rx)."

National Headache Foundation: "Calcium Channel Blockers."

Mayo Clinic: "Migraine treatment: Can antidepressants help?"

PubChem Open Chemistry Database: "Amitriptyline," "Noritriptyline."

Consumer Reports : "Amitriptyline May Help Reduce Migraine Frequency."

American Migraine Foundation: "Botox for Migraine," "Calcitonin Gene-Related Peptide Targeted Therapy for Migraine."

NHS Choices: "Migraine - Prevention."

UpToDate: "Chronic Migraine."

Reviewed by Melinda Ratini on May 20, 2018

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Can nonsteroidal anti-inflammatory drugs (NSAIDs) help prevent menstrual migraine?

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