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How can calcitonin gene-related peptide (CGRP) inhibitors help treat migraine?

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CGRP (calcitonin gene-related peptide) is a molecule involved in causing migraine pain. CGRP inhibitors are a new class of drugs that block the effects of CGRP. Erenumab (Aimovig) is the first medicine specifically approved to prevent migraine attacks. You give yourself an injection once a month with a pen-like device. In clinical trials, people consistently had one to two fewer migraine days a month than those who took placebo. Mild pain and redness at the injection site are the most common side effects.

SOURCES:

The Migraine Trust: "Preventive medicines."

American Family Physician : "Medications for Migraine Prophylaxis."

Progress in Cardiovascular Nursing : "Cardiovascular Effects of Migraine Therapy."

Harvard Health Publishing: "Migraines: Stop them before they start."

Headache : "Beta-Blockers for Migraine."

Medscape: "verapamil (Rx)."

National Headache Foundation: "Calcium Channel Blockers."

Mayo Clinic: "Migraine treatment: Can antidepressants help?"

PubChem Open Chemistry Database: "Amitriptyline," "Noritriptyline."

Consumer Reports : "Amitriptyline May Help Reduce Migraine Frequency."

American Migraine Foundation: "Botox for Migraine," "Calcitonin Gene-Related Peptide Targeted Therapy for Migraine."

NHS Choices: "Migraine - Prevention."

UpToDate: "Chronic Migraine."

Reviewed by Melinda Ratini on May 20, 2018

SOURCES:

The Migraine Trust: "Preventive medicines."

American Family Physician : "Medications for Migraine Prophylaxis."

Progress in Cardiovascular Nursing : "Cardiovascular Effects of Migraine Therapy."

Harvard Health Publishing: "Migraines: Stop them before they start."

Headache : "Beta-Blockers for Migraine."

Medscape: "verapamil (Rx)."

National Headache Foundation: "Calcium Channel Blockers."

Mayo Clinic: "Migraine treatment: Can antidepressants help?"

PubChem Open Chemistry Database: "Amitriptyline," "Noritriptyline."

Consumer Reports : "Amitriptyline May Help Reduce Migraine Frequency."

American Migraine Foundation: "Botox for Migraine," "Calcitonin Gene-Related Peptide Targeted Therapy for Migraine."

NHS Choices: "Migraine - Prevention."

UpToDate: "Chronic Migraine."

Reviewed by Melinda Ratini on May 20, 2018

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