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What drugs are used to prevent migraines?

ANSWER

Drugs used to prevent migraines include:

Although they can offer some help, they were made to treat other health problems. Their effect on migraines was discovered by chance. Some work better for some people than for others, and side effects are common.

  • Antidepressants: amitriptyline and venlafaxine (Effexor)
  • Anti-seizure drugs: gabapentin (Neurontin), topiramate (Qudexy XR, Topamax, Trokendi XR) and valproate (Depakote)  
  • Beta-blockers: metoprolol, propranolol, and timolol
  • CGRP Inhibitors: erenumab (Aimovig), fremanezumab (Ajovy), and galcanezumab-gnlm (Emgality )

NeuroSciences : “New advances in prevention of migraine: Review of current practice and recent advances.”

Functional Neurology : “Migraine as a complex disease: heterogeneity, comorbidity and genotype-phenotype interactions.”

National Headache Foundation: “Facts about Triptans,” “Migraine.”

Expert Reviews of Clinical Pharmacology : “The Pathophysiological and Pharmacological Basis of Current Drug Treatment of Migraine Headache.”

Mayo Clinic: “Migraine: Treatment.”

The Lancet Neurology : “Effects of tonabersat on migraine with aura: a randomized, double-blind, placebo-controlled crossover study,” “Headache research in 2015: progress in migraine treatment.”

Neurology : “TEV-48125 for the preventive treatment of chronic migraine.”

Hormone Health Network/Endocrine Society: “What Do Prostaglandins Do?”

Current Opinion in Neurology : “Prostaglandins in migraine: update.”

The DANA Foundation: “Theory Behind Migraine Emerges.”

The Migraine Trust: “Transcranial magnetic stimulation (TMS).”

American Migraine Foundation: “Behavioral Treatment of Headache and Migraine Patients -- Making Referrals,” “Biofeedback and Relaxation Training for Headaches.”

Medscape: “Phase 3 STRIVE and ARISE Trials Show Efficacy, Safety for Erenumab in Migraine Prevention,” “Positive Phase 3 Results for Fremanezumab in Migraine.”

Reviewed by Melinda Ratini on February 18, 2019

NeuroSciences : “New advances in prevention of migraine: Review of current practice and recent advances.”

Functional Neurology : “Migraine as a complex disease: heterogeneity, comorbidity and genotype-phenotype interactions.”

National Headache Foundation: “Facts about Triptans,” “Migraine.”

Expert Reviews of Clinical Pharmacology : “The Pathophysiological and Pharmacological Basis of Current Drug Treatment of Migraine Headache.”

Mayo Clinic: “Migraine: Treatment.”

The Lancet Neurology : “Effects of tonabersat on migraine with aura: a randomized, double-blind, placebo-controlled crossover study,” “Headache research in 2015: progress in migraine treatment.”

Neurology : “TEV-48125 for the preventive treatment of chronic migraine.”

Hormone Health Network/Endocrine Society: “What Do Prostaglandins Do?”

Current Opinion in Neurology : “Prostaglandins in migraine: update.”

The DANA Foundation: “Theory Behind Migraine Emerges.”

The Migraine Trust: “Transcranial magnetic stimulation (TMS).”

American Migraine Foundation: “Behavioral Treatment of Headache and Migraine Patients -- Making Referrals,” “Biofeedback and Relaxation Training for Headaches.”

Medscape: “Phase 3 STRIVE and ARISE Trials Show Efficacy, Safety for Erenumab in Migraine Prevention,” “Positive Phase 3 Results for Fremanezumab in Migraine.”

Reviewed by Melinda Ratini on February 18, 2019

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What is the treatment for tension headaches?

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