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How is the drug pregabalin (Lyrica) used off-label to help treat MS?

ANSWER

This is an option for treating pain from MS. It looks to be safe with few side effects.

SOURCES:

National Multiple Sclerosis Society: "Non-approved treatments used for MS disease modification," "Amantadine," "Pain."

Multiple Sclerosis Society of Canada: "Common acne medication offers new treatment for multiple sclerosis."

U.S. National Library of Medicine: "Current and emerging therapies in multiple sclerosis: a systematic review," "Ten Common Questions (and Their Answers) About Off-label Drug Use," "Azathioprine for multiple sclerosis," "Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis," "A Randomized Placebo-Controlled Trial of Duloxetine for Central Pain in Multiple Sclerosis," "Duloxetine is effective in treating depression in multiple sclerosis patients: an open-label multicenter study."

Biogen: "Avonex Medication Guide."

FDA: "Understanding Unapproved Use of Approved Drugs "Off Label"."

Journal of the American Medical Association : "Association of Off-label Drug Use and Adverse Drug Events in an Adult Population."

American Cancer Society: "Off-Label Drug Use."

Medscape: "Multiple Sclerosis Medication," "Cladribine Back in the Running for Multiple Sclerosis," "Cladribine ( ) for MS Approved in Europe." Mavenclad

Cleveland Clinic: "Azathioprine and Multiple Sclerosis."

Multiple Sclerosis Trust: "Cyclophosphamide (Endoxana)," "Modafinil (Provigil)," "Pregabalin (Lyrica)."

Partners Multiple Sclerosis Center: "Cyclophosphamide (Cytoxan)."

Tisch MS Research Center of New York: "Safety of Long-term Intrathecal Methotrexate Therapy in Progressive Forms of Multiple Sclerosis."

Reviewed by Jennifer Robinson on May 30, 2019

SOURCES:

National Multiple Sclerosis Society: "Non-approved treatments used for MS disease modification," "Amantadine," "Pain."

Multiple Sclerosis Society of Canada: "Common acne medication offers new treatment for multiple sclerosis."

U.S. National Library of Medicine: "Current and emerging therapies in multiple sclerosis: a systematic review," "Ten Common Questions (and Their Answers) About Off-label Drug Use," "Azathioprine for multiple sclerosis," "Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis," "A Randomized Placebo-Controlled Trial of Duloxetine for Central Pain in Multiple Sclerosis," "Duloxetine is effective in treating depression in multiple sclerosis patients: an open-label multicenter study."

Biogen: "Avonex Medication Guide."

FDA: "Understanding Unapproved Use of Approved Drugs "Off Label"."

Journal of the American Medical Association : "Association of Off-label Drug Use and Adverse Drug Events in an Adult Population."

American Cancer Society: "Off-Label Drug Use."

Medscape: "Multiple Sclerosis Medication," "Cladribine Back in the Running for Multiple Sclerosis," "Cladribine ( ) for MS Approved in Europe." Mavenclad

Cleveland Clinic: "Azathioprine and Multiple Sclerosis."

Multiple Sclerosis Trust: "Cyclophosphamide (Endoxana)," "Modafinil (Provigil)," "Pregabalin (Lyrica)."

Partners Multiple Sclerosis Center: "Cyclophosphamide (Cytoxan)."

Tisch MS Research Center of New York: "Safety of Long-term Intrathecal Methotrexate Therapy in Progressive Forms of Multiple Sclerosis."

Reviewed by Jennifer Robinson on May 30, 2019

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