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What are side effects and warnings associated with teriflunomide (Aubagio), which treats the relapsing form of multiple sclerosis?

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Teriflunomide (Aubagio) is a drug you take by mouth to treat the relapsing form of MS. It’s a tablet you take once a day. The most common side effects include diarrhea, abnormal liver tests, nausea, and hair loss. Aubagio does carry a "black box" warning -- the FDA's most serious warning -- because of liver problems and birth defects. If you take this medicine, your doctor will likely do regular tests to check how well your liver is working -- and you shouldn't take this drug if you're pregnant.

National Multiple Sclerosis Society: "Disease Management Consensus Statement," "Fingolimod," "Novantrone (mitoxantrone),"  "Exacerbations,"  "FDA Approves Plegridy (Pegylated Interferon Beta) For Relapsing MS."

John Ratchford, MD, assistant professor of neurology, Johns Hopkins School of Medicine.

NINDS: "Multiple Sclerosis Information Page."

Goldman, L.  , Saunders Elsevier, 2007. Cecil Medicine

FDA: "Safety Update on Progressive Multifocal Leukoencephalopathy (PML) Associated with Tysabri," "FDA approves new multiple sclerosis treatment Aubagio," "FDA investigating rare brain infection in patient taking Gilenya (fingolimod)."

Reviewed by Christopher Melinosky on June 29, 2020

National Multiple Sclerosis Society: "Disease Management Consensus Statement," "Fingolimod," "Novantrone (mitoxantrone),"  "Exacerbations,"  "FDA Approves Plegridy (Pegylated Interferon Beta) For Relapsing MS."

John Ratchford, MD, assistant professor of neurology, Johns Hopkins School of Medicine.

NINDS: "Multiple Sclerosis Information Page."

Goldman, L.  , Saunders Elsevier, 2007. Cecil Medicine

FDA: "Safety Update on Progressive Multifocal Leukoencephalopathy (PML) Associated with Tysabri," "FDA approves new multiple sclerosis treatment Aubagio," "FDA investigating rare brain infection in patient taking Gilenya (fingolimod)."

Reviewed by Christopher Melinosky on June 29, 2020

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What is Gilenya and how is it used to treat multiple sclerosis?

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