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What causes the shift from relapsing-remitting multiple sclerosis (MS) to secondary progressive multiple sclerosis (MS)?

ANSWER

It's unclear why the disease makes the shift, but scientists know a few things about the process:

  • The older a person is when she’s first diagnosed, the shorter the time she has before the disease becomes secondary progressive.
  • People who don’t fully recover from relapses generally move to secondary progressive MS sooner than those who do.
  • The process of ongoing nerve damage changes. After the transformation, there's less inflammation and more of a slow decline in how well the nerves work.

SOURCES:

Miller, D. , 2007. Lancet Neurology

Goetz, C. 3rd edition, Saunders, 2007. Textbook of Clinical Neurology,

Rovaris, M. , 2006. Lancet Neurology

Tullma,n M. , 2004. Multiple Sclerosis

Acherio, A. , 2007. Annals of Neurology

Sadovnick, A. , 1993. Annals of Neurology

DeStefano, F. , 2003. Archives of Neurology

National MS Society: "Viruses."

Reviewed by Christopher Melinosky on August 26, 2019

SOURCES:

Miller, D. , 2007. Lancet Neurology

Goetz, C. 3rd edition, Saunders, 2007. Textbook of Clinical Neurology,

Rovaris, M. , 2006. Lancet Neurology

Tullma,n M. , 2004. Multiple Sclerosis

Acherio, A. , 2007. Annals of Neurology

Sadovnick, A. , 1993. Annals of Neurology

DeStefano, F. , 2003. Archives of Neurology

National MS Society: "Viruses."

Reviewed by Christopher Melinosky on August 26, 2019

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Do hot temperatures affect multiple sclerosis symptoms?

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