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What is the use of nanomedicine in treating multiple sclerosis (MS)?

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In some cases, nanoparticles act as tiny cargo ships that carry medicine -- sometimes, to parts of the body drugs can’t reach on their own. For example, they can cross the blood-brain barrier, a layer of cells that protect your brain from possible danger -- but that also keep helpful MS drugs from getting through.

Attaching MS drugs to nanoparticles may solve this problem. That’s because certain nanoparticles can interact with blood-brain barrier cells and get “swallowed” by them. When the nanoparticle gets in, so does the drug it carries.

Another type of nanoparticle doesn’t even need to carry medicine. The material itself is a powerful antioxidant that crosses the blood-brain barrier. It’s called a cerium oxide nanoparticle, and it helped relieve some MS symptoms in mice.

From: Multiple Sclerosis Research Roundup WebMD Medical Reference

National Multiple Sclerosis Society: “Bone Marrow Stem Cell Transplant -- HSCT,” “Ending the Disease Forever,” “Multiple Sclerosis FAQs,” “News Release,” “Restoring What’s Been Lost,” “Searching for MS Genes,” “Stopping MS in its Tracks.”

Mayo Clinic: “Bone Marrow Transplant: Overview,” “Bone Marrow Transplant: Why it’s done.”

National Institutes of Health: “Nanotechnology at NIH.”

Advanced Pharmaceutical Bulletin : “Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective.”

ACS Nano : “Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain.”

PNAS : “In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.”

Journal of Immunotoxicology : “Application of nanomedicine for crossing the blood-brain barrier: Theranostic opportunities in multiple sclerosis.”

Reviewed by Neil Lava on May 05, 2019

National Multiple Sclerosis Society: “Bone Marrow Stem Cell Transplant -- HSCT,” “Ending the Disease Forever,” “Multiple Sclerosis FAQs,” “News Release,” “Restoring What’s Been Lost,” “Searching for MS Genes,” “Stopping MS in its Tracks.”

Mayo Clinic: “Bone Marrow Transplant: Overview,” “Bone Marrow Transplant: Why it’s done.”

National Institutes of Health: “Nanotechnology at NIH.”

Advanced Pharmaceutical Bulletin : “Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective.”

ACS Nano : “Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain.”

PNAS : “In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.”

Journal of Immunotoxicology : “Application of nanomedicine for crossing the blood-brain barrier: Theranostic opportunities in multiple sclerosis.”

Reviewed by Neil Lava on May 05, 2019

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