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What medications are used to manage symptoms of multiple sclerosis?

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To target specific symptoms of multiple sclerosis, your doctor may recommend:

  • Muscle relaxants such as baclofen (Lioresal) and tizanidine (Zanaflex) or sedatives like clonazepam (Klonopin) and diazepam (Valium), for muscle stiffness and spasms
  • Amantadine (Symmetrel), armodafinil (Nuvigil), modafinil (Provogil), for fatigue
  • Antidepressants, such as bupropion (Wellbutrin), fluoxetine (Prozac), and sertraline (Zoloft), for depression
  • Oxybutynin (Ditropan) or tolterodine (Detrol), for bladder problems

From: Treatments for Multiple Sclerosis WebMD Medical Reference

National Multiple Sclerosis Society: "Disease Management Consensus Statement," "Fingolimod," "Novantrone (mitoxantrone),"  "Exacerbations,"  "FDA Approves Plegridy (Pegylated Interferon Beta) For Relapsing MS."

John Ratchford, MD, assistant professor of neurology, Johns Hopkins School of Medicine.

NINDS: "Multiple Sclerosis Information Page."

Goldman, L.  , Saunders Elsevier, 2007. Cecil Medicine

FDA: "Safety Update on Progressive Multifocal Leukoencephalopathy (PML) Associated with Tysabri," "FDA approves new multiple sclerosis treatment Aubagio," "FDA investigating rare brain infection in patient taking Gilenya (fingolimod)."

Reviewed by Neil Lava on March 13, 2018

National Multiple Sclerosis Society: "Disease Management Consensus Statement," "Fingolimod," "Novantrone (mitoxantrone),"  "Exacerbations,"  "FDA Approves Plegridy (Pegylated Interferon Beta) For Relapsing MS."

John Ratchford, MD, assistant professor of neurology, Johns Hopkins School of Medicine.

NINDS: "Multiple Sclerosis Information Page."

Goldman, L.  , Saunders Elsevier, 2007. Cecil Medicine

FDA: "Safety Update on Progressive Multifocal Leukoencephalopathy (PML) Associated with Tysabri," "FDA approves new multiple sclerosis treatment Aubagio," "FDA investigating rare brain infection in patient taking Gilenya (fingolimod)."

Reviewed by Neil Lava on March 13, 2018

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