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Can a tricyclic antidepressant help treat osteoarthritis (OA) pain?

ANSWER

Doctors sometimes prescribe a tricyclic antidepressant such as amitriptyline, desipramine (Norpramin), and nortriptyline (Pamelor) for chronic pain. These are most often taken near bedtime because of sedative effects. Other side effects include dry mouth, nausea, weight change, and constipation.

SOURCES:

News release, FDA.

American College of Rheumatology: Practice Guidelines: "Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee."

The Arthritis Foundation: "What Can You Do About OA?" "2011 Drug Guide."

FDA: "Medication Guide for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)."

Reviewed by David Zelman on September 11, 2019

SOURCES:

News release, FDA.

American College of Rheumatology: Practice Guidelines: "Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee."

The Arthritis Foundation: "What Can You Do About OA?" "2011 Drug Guide."

FDA: "Medication Guide for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)."

Reviewed by David Zelman on September 11, 2019

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Can injectable corticosteroids help treat osteoarthritis (OA) pain?

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