The Truth About Vitamin D: Drug Interactions

WebMD feature series on vitamin D.

From the WebMD Archives

Does vitamin D interact with other medications?

Yes. Steroid medications such as prednisone can interfere with vitamin D metabolism. If you take steroid drugs regularly, discuss vitamin D with your doctor.

The weight loss drug orlistat -- brand names include Xenical and Alli -- may cut absorption of vitamin D. So does the cholesterol-lowering drug cholestyramine (sold as Questran, LoCholest, and Prevalite). People taking these drugs should discuss vitamin intake with their doctors.

The seizure drugs Phenobarbital and Dilantin (phenytoin), affect vitamin D metabolism and affect calcium absorption. So do anti-tuberculosis drugs.

On the other hand, cholesterol-lowering statin drugs and thiazide diuretics increase vitamin D levels.

First: Introduction to vitamin D next button

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WebMD Feature Reviewed by Brunilda Nazario, MD on December 17, 2009

Sources

SOURCES:

Cannell, J.J. and Hollis, B.W. Alternative Medicine Review, March 2008; vol 13: pp 6-20.

Holick, M.F. Journal of Clinical Endocrinology and Metabolism, March 2008; vol 93: pp 677-681.

Autier, P. and Gandini, S. Archives of Internal Medicine, Sept. 10, 2007; vol 167: pp 1730-1737.

Holick, M.F. and Chen, T.C. American Journal of Clinical Nutrition, 2008; vol 87: pp 1080S-1086S.

Bordelon, P. American Family Physician, Oct. 15, 2009; vol 80: pp 841-846.

Rovner, A.J. and O'Brien, K.O. Archives of Pediatric and Adolescent Medicine, June 2008; vol 162: pp 513-519.

Pepper, K.J. Endocrinology Practice, 2009; vol 15: pp 95-103.

WebMD Health News: " Vitamin D Deficiency Worsens Breast Cancer?"

WebMD Feature: " Are You Getting Enough Vitamin D?"

WebMD Health News: " Vitamin D Deficiency May Hurt Heart."

WebMD Health News: " Calcium/Vitamin D Slows Weight Gain."

WebMD Health News: " Vitamin D Fights Colon Cancer."

WebMD Health News: " Vitamin D Compounds May Fight Prostate Cancer."

National Institutes of Health Office of Dietary Supplements, Dietary Supplement Fact Sheet: Vitamin D, updated Nov. 13, 2009.

The Vitamin D Council web site.

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