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Alzheimer’s Drug May Help Preemies

Namenda May Help Prevent Brain Damage in Premature Infants

Reviewed by Louise Chang, MD on June 24, 2008
From the WebMD Archives

June 24, 2008 -- A drug used to treat older patients with Alzheimer's disease may help protect the youngest premature infants from harm.

A new study suggests that Namenda, a drug originally developed to treat Alzheimer's disease, may help break the cycle of brain damage many premature infants face.

Researchers found that rats treated with Namenda suffered less brain damage after a loss of oxygen and blood supply to the brain, a common problem in premature infants because of underdeveloped organs.

These findings are only preliminary and must be replicated in humans, but researchers say the results may offer a new avenue for treating and potentially preventing brain damage among premature infants. No such treatment exists.

Protecting Premature Brains

An increase in the number of multiple births has led to a rise in the number of premature births in the U.S. Although advances in medicine have meant improved survival rates for most premature infants, up to 35% of premature infants suffer from lasting brain damage, which can lead to learning difficulties and conditions like cerebral palsy.

Researchers say the problem in developing treatments to prevent brain damage in premature infants is that the premature brain behaves very differently from the adult brain.

"The premature brain is not just a 'small' adult brain -- it is physiologically different and thus contains unique targets for therapy," says researcher Frances Jensen, MD, of Children's Hospital Boston, in a news release.

Jensen says a loss of blood and oxygen to the brain appears to act upon brain cells known as oligodendrocytes in the premature brain. Immature forms of these cells are particularly vulnerable to damage during development.

(Does your child have cerebral palsy? How are you coping? Find other parents like you on WebMD's Parenting: Special Needs Children message board.)

Namenda Targets Vulnerable Brain Cells

In this study, published in the Journal of Neuroscience, researchers first confirmed the presence of NMDA receptors in premature brains of humans as well as rats. NMDA receptors are targeted by Namenda.

Then researchers tested the effects of a loss of oxygen and blood supply on oligodendrocytes treated with Namenda. Without treatment, the loss of blood and oxygen supply triggered an over-activation of the NMDA receptors, leading to brain damage and loss of white matter.

But when rat pups were treated with Namenda after the episode, the rats suffered less immediate and long-term injury.

Researchers say the next step will be to evaluate the potential safety risks of treating newborns with Namenda and conducting clinical trials.

Show Sources

SOURCES:

Manning, S. Journal of Neuroscience, June 25, 2008; vol 28.

News release, Children's Hospital Boston.

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