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How can catechol-O-methyl transferase (COMT) inhibitors help with treating Parkinson's disease?

ANSWER

COMT inhibitors add to the amount of time you get relief from symptoms by blocking the action of an enzyme that breaks down levodopa. You take these drugs, such as tolcapone (Tasmar) and entacapone (Comtan), along with levodopa. Tolcapone is rarely prescribed by doctors, though, because it can cause liver damage.

Stalevo is a tablet that combines carbidopa/levodopa with entacapone. While carbidopa lessens the side effects of levodopa, entacapone adds to the time levodopa is active in the brain.

SOURCES: 

Journal of the American Medical Association

American Academy of Family Physicians. 

National Parkinson Foundation. 

American Parkinson Disease Foundation. 

Parkinson's UK: "Wearing Off and Dyskinesia."

Teva Pharmaceuticals Inc.

FDA. "FDA approves drug to treat Parkinson’s disease."  

Reviewed by Neil Lava on January 20, 2019

SOURCES: 

Journal of the American Medical Association

American Academy of Family Physicians. 

National Parkinson Foundation. 

American Parkinson Disease Foundation. 

Parkinson's UK: "Wearing Off and Dyskinesia."

Teva Pharmaceuticals Inc.

FDA. "FDA approves drug to treat Parkinson’s disease."  

Reviewed by Neil Lava on January 20, 2019

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How can monoamine oxidase B (MAO-B) inhibitors help with treating Parkinson's disease?

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