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New Prostate Cancer Marker Found

Marker Is a Protein That May Predict Aggressive Prostate Cancer

Medically Reviewed by Louise Chang, MD on August 15, 2007

Aug. 15, 2007 -- Scientists today announced that they have spotted a potential marker of aggressive prostate cancer.

The marker, called B7-H3, is a protein that's involved in the body's immune system.

Mayo Clinic doctors including Timothy Roth, MD, report that B7-H3 is more abundant in prostate cancers than in normal prostate tissue and is especially plentiful in aggressive prostate cancers.

Roth's team tested prostate tissue from 338 men with prostate cancer who had their prostates surgically removed between 1995 and 1998.

All of the men had B7-H3 in their prostate tumors. They also had B7-H3 in normal prostate tissue, to a lesser extent. The researchers tracked the men's prostate cancer for up to nine years.

During that time, prostate cancer worsened in 93 of the patients. Those patients generally had higher B7-H3 levels in their prostate tumors than men whose prostate cancer didn't worsen during the study period.

The researchers suggest that B7-H3 may help doctors gauge whether a patient has aggressive prostate cancer that needs early, aggressive treatment.

B7-H3 may also make a good target for new prostate cancer drugs, according to Roth and colleagues.

But don't expect that to happen right away. First, scientists must learn exactly what B7-H3 does and how to target it in prostate tumors without affecting healthy cells.

The study appears in the journal Cancer Research.

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SOURCES: Roth, T. Cancer Research, Aug. 15, 2007; vol 67: pp 7893-7900. News release, Mayo Clinic.

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