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How does a PSA test show that prostate cancer may have come back after prostate removal surgery?

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Only the prostate gland releases PSA. After the prostate is removed, you PSA level should drop to almost zero within 4 weeks. A test result above 0.2 ng/mL a few months after your surgery could be a sign that your cancer has come back. This is called a biochemical recurrence.

SOURCES:

American Cancer Society: "Following PSA Levels During and After Prostate Cancer Treatment."

American Urological Association: "PSA Testing for the Pretreatment Staging and Posttreatment Management of Prostate Cancer."

British Journal of Medical and Surgical Urology: "PSA velocity and doubling time in diagnosis and prognosis of prostate cancer."

Harvard Medical School: "Immediate radiation when PSA levels spike after prostate cancer surgery helps reduce risk of recurrence."

Johns Hopkins Medicine: "Radical Prostatectomy," "Top Prostate Cancer Questions," "What Happens if PSA Comes Back After Surgery?"

Mayo Clinic: "PSA Test."

National Cancer Institute: "Prostate-Specific Antigen (PSA) Test."

NCCN: "Guidelines for Patients: Prostate Cancer."

Prostate Cancer Foundation: "PSA Rising."

Urology: "Timing of PSA nadir after radical prostatectomy and risk of biochemical recurrence."

U.S. Preventive Services Task Force: "Prostate Cancer: Screening."

Reviewed by Nazia Q Bandukwala on December 11, 2019

SOURCES:

American Cancer Society: "Following PSA Levels During and After Prostate Cancer Treatment."

American Urological Association: "PSA Testing for the Pretreatment Staging and Posttreatment Management of Prostate Cancer."

British Journal of Medical and Surgical Urology: "PSA velocity and doubling time in diagnosis and prognosis of prostate cancer."

Harvard Medical School: "Immediate radiation when PSA levels spike after prostate cancer surgery helps reduce risk of recurrence."

Johns Hopkins Medicine: "Radical Prostatectomy," "Top Prostate Cancer Questions," "What Happens if PSA Comes Back After Surgery?"

Mayo Clinic: "PSA Test."

National Cancer Institute: "Prostate-Specific Antigen (PSA) Test."

NCCN: "Guidelines for Patients: Prostate Cancer."

Prostate Cancer Foundation: "PSA Rising."

Urology: "Timing of PSA nadir after radical prostatectomy and risk of biochemical recurrence."

U.S. Preventive Services Task Force: "Prostate Cancer: Screening."

Reviewed by Nazia Q Bandukwala on December 11, 2019

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How often do you take a PSA test after prostate removal surgery?

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