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How does a rheumatoid arthritis (RA) vaccine work?

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Rheumavax is an immunotherapy treatment that boosts your body’s natural defenses. It's designed for people who either have certain genes that make them more likely to have RA, or who have antibodies called anti-CCP in their blood. Doctors usually test anti-CCP levels early on in the disease to predict how bad your RA might get.

Rheumavax should work for most people with RA. The vaccine works by training your immune system not to “see” the peptide that typically triggers RA. To help the learning process along, a doctor takes a sample of your blood and takes out cells called dendrites and changes them so they react differently. The Rheumavax vaccine is a single shot of these changed cells back into your body.

SOURCES:

Johns Hopkins Arthritis Center: “Rheumatoid Arthritis.” 

Stem Cell Reports : “Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.” 

Katalin Mikecz, MD, PhD, professor, department of orthopedic surgery, Rush Medical College, Chicago. 

Biomedical Reports : “TNF Inhibitor therapy for rheumatoid arthritis.”

Vaccine : “An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.”

Expert Review of Vaccines : “Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis."

Science Translational Medicine : “Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.”

Annals of the Rheumatic Diseases : “Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.”

Reviewed by David Zelman on October 03, 2018

SOURCES:

Johns Hopkins Arthritis Center: “Rheumatoid Arthritis.” 

Stem Cell Reports : “Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.” 

Katalin Mikecz, MD, PhD, professor, department of orthopedic surgery, Rush Medical College, Chicago. 

Biomedical Reports : “TNF Inhibitor therapy for rheumatoid arthritis.”

Vaccine : “An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.”

Expert Review of Vaccines : “Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis."

Science Translational Medicine : “Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.”

Annals of the Rheumatic Diseases : “Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis.”

Reviewed by David Zelman on October 03, 2018

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Is a rheumatoid arthritis (RA) vaccine available for treatment?

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